MSI-low, a real phenomenon which varies in frequency among cancer types

Sarah E R Halford; Elinor J. Sawyer; Maryou B. Lambros; Patricia Gorman; Nicola D. Macdonald; Ian C. Talbot; William D. Foulkes; Cheryl E. Gillett; Diana M. Barnes; Lars A. Akslen; Kwok Lee; Ian J. Jacobs; Andrew M. Hanby; Trivadi S. Ganesan; Helga B. Salvesen; Walter F. Bodmer; Ian P M Tomlinson; Rebecca R. Roylance

doi:10.1002/path.1453

MSI-low, a real phenomenon which varies in frequency among cancer types

Sarah E R Halford, Elinor J. Sawyer, Maryou B. Lambros, Patricia Gorman, Nicola D. Macdonald, Ian C. Talbot, William D. Foulkes, Cheryl E. Gillett, Diana M. Barnes, Lars A. Akslen, Kwok Lee, Ian J. Jacobs, Andrew M. Hanby, Trivadi S. Ganesan, Helga B. Salvesen, Walter F. Bodmer, Ian P M Tomlinson, Rebecca R. Roylance

Research output: Contribution to journal › Article › peer-review

Abstract

This study assessed whether low-level microsatellite instability (MSI-L) is a phenomenon specific to colorectal cancers or is also present in other tumour types. Breast (grade III ductal and lobular), endometrial and ovarian carcinomas, as well as colorectal cancers, were analysed for MSI-L using eight microsatellite markers. The markers were selected from a panel that had previously been shown to be sensitive for the detection of MSI-L in colorectal cancers. It was found that MSI-L was present in 30 of 87 (35%) colorectal cancers, 2 of 59 (3%) grade III breast carcinomas, 1 of 35 (3%) lobular breast cancers, 16 of 50 (32%) endometrial cancers, and 9 of 34 (26%) ovarian cancers. These results suggest that MSI-L is a very rare occurrence in breast carcinomas, but does occur as a real phenomenon in colorectal, endometrial, and ovarian carcinomas, which are all part of the hereditary nonpolyposis colon cancer (HNPCC) syndrome. PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem. Copyright © 2003 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	389-394
Number of pages	5
Journal	Journal of Pathology
Volume	201
Issue number	3
DOIs	https://doi.org/10.1002/path.1453
Publication status	Published - Nov 2003

Keywords

Breast cancer
Colorectal cancer
Endometrial cancer
HNPCC
Microsatellite instability
MSI-L
MSI-low
Ovarian cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/path.1453

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Halford, S. E. R., Sawyer, E. J., Lambros, M. B., Gorman, P., Macdonald, N. D., Talbot, I. C., Foulkes, W. D., Gillett, C. E., Barnes, D. M., Akslen, L. A., Lee, K., Jacobs, I. J., Hanby, A. M., Ganesan, T. S., Salvesen, H. B., Bodmer, W. F., Tomlinson, I. P. M., & Roylance, R. R. (2003). MSI-low, a real phenomenon which varies in frequency among cancer types. Journal of Pathology, 201(3), 389-394. https://doi.org/10.1002/path.1453

@article{382e1a63689e4276b93f563eeb4d85f0,

title = "MSI-low, a real phenomenon which varies in frequency among cancer types",

abstract = "This study assessed whether low-level microsatellite instability (MSI-L) is a phenomenon specific to colorectal cancers or is also present in other tumour types. Breast (grade III ductal and lobular), endometrial and ovarian carcinomas, as well as colorectal cancers, were analysed for MSI-L using eight microsatellite markers. The markers were selected from a panel that had previously been shown to be sensitive for the detection of MSI-L in colorectal cancers. It was found that MSI-L was present in 30 of 87 (35%) colorectal cancers, 2 of 59 (3%) grade III breast carcinomas, 1 of 35 (3%) lobular breast cancers, 16 of 50 (32%) endometrial cancers, and 9 of 34 (26%) ovarian cancers. These results suggest that MSI-L is a very rare occurrence in breast carcinomas, but does occur as a real phenomenon in colorectal, endometrial, and ovarian carcinomas, which are all part of the hereditary nonpolyposis colon cancer (HNPCC) syndrome. PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem. Copyright {\textcopyright} 2003 John Wiley & Sons, Ltd.",

keywords = "Breast cancer, Colorectal cancer, Endometrial cancer, HNPCC, Microsatellite instability, MSI-L, MSI-low, Ovarian cancer",

author = "Halford, {Sarah E R} and Sawyer, {Elinor J.} and Lambros, {Maryou B.} and Patricia Gorman and Macdonald, {Nicola D.} and Talbot, {Ian C.} and Foulkes, {William D.} and Gillett, {Cheryl E.} and Barnes, {Diana M.} and Akslen, {Lars A.} and Kwok Lee and Jacobs, {Ian J.} and Hanby, {Andrew M.} and Ganesan, {Trivadi S.} and Salvesen, {Helga B.} and Bodmer, {Walter F.} and Tomlinson, {Ian P M} and Roylance, {Rebecca R.}",

year = "2003",

month = nov,

doi = "10.1002/path.1453",

language = "English",

volume = "201",

pages = "389--394",

journal = "Journal of Pathology",

issn = "0022-3417",

publisher = "John Wiley & Sons Ltd",

number = "3",

}

Halford, SER, Sawyer, EJ, Lambros, MB, Gorman, P, Macdonald, ND, Talbot, IC, Foulkes, WD, Gillett, CE, Barnes, DM, Akslen, LA, Lee, K, Jacobs, IJ, Hanby, AM, Ganesan, TS, Salvesen, HB, Bodmer, WF, Tomlinson, IPM & Roylance, RR 2003, 'MSI-low, a real phenomenon which varies in frequency among cancer types', Journal of Pathology, vol. 201, no. 3, pp. 389-394. https://doi.org/10.1002/path.1453

TY - JOUR

T1 - MSI-low, a real phenomenon which varies in frequency among cancer types

AU - Halford, Sarah E R

AU - Sawyer, Elinor J.

AU - Lambros, Maryou B.

AU - Gorman, Patricia

AU - Macdonald, Nicola D.

AU - Talbot, Ian C.

AU - Foulkes, William D.

AU - Gillett, Cheryl E.

AU - Barnes, Diana M.

AU - Akslen, Lars A.

AU - Lee, Kwok

AU - Jacobs, Ian J.

AU - Hanby, Andrew M.

AU - Ganesan, Trivadi S.

AU - Salvesen, Helga B.

AU - Bodmer, Walter F.

AU - Tomlinson, Ian P M

AU - Roylance, Rebecca R.

PY - 2003/11

Y1 - 2003/11

N2 - This study assessed whether low-level microsatellite instability (MSI-L) is a phenomenon specific to colorectal cancers or is also present in other tumour types. Breast (grade III ductal and lobular), endometrial and ovarian carcinomas, as well as colorectal cancers, were analysed for MSI-L using eight microsatellite markers. The markers were selected from a panel that had previously been shown to be sensitive for the detection of MSI-L in colorectal cancers. It was found that MSI-L was present in 30 of 87 (35%) colorectal cancers, 2 of 59 (3%) grade III breast carcinomas, 1 of 35 (3%) lobular breast cancers, 16 of 50 (32%) endometrial cancers, and 9 of 34 (26%) ovarian cancers. These results suggest that MSI-L is a very rare occurrence in breast carcinomas, but does occur as a real phenomenon in colorectal, endometrial, and ovarian carcinomas, which are all part of the hereditary nonpolyposis colon cancer (HNPCC) syndrome. PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem. Copyright © 2003 John Wiley & Sons, Ltd.

AB - This study assessed whether low-level microsatellite instability (MSI-L) is a phenomenon specific to colorectal cancers or is also present in other tumour types. Breast (grade III ductal and lobular), endometrial and ovarian carcinomas, as well as colorectal cancers, were analysed for MSI-L using eight microsatellite markers. The markers were selected from a panel that had previously been shown to be sensitive for the detection of MSI-L in colorectal cancers. It was found that MSI-L was present in 30 of 87 (35%) colorectal cancers, 2 of 59 (3%) grade III breast carcinomas, 1 of 35 (3%) lobular breast cancers, 16 of 50 (32%) endometrial cancers, and 9 of 34 (26%) ovarian cancers. These results suggest that MSI-L is a very rare occurrence in breast carcinomas, but does occur as a real phenomenon in colorectal, endometrial, and ovarian carcinomas, which are all part of the hereditary nonpolyposis colon cancer (HNPCC) syndrome. PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem. Copyright © 2003 John Wiley & Sons, Ltd.

KW - Breast cancer

KW - Colorectal cancer

KW - Endometrial cancer

KW - HNPCC

KW - Microsatellite instability

KW - MSI-L

KW - MSI-low

KW - Ovarian cancer

U2 - 10.1002/path.1453

DO - 10.1002/path.1453

M3 - Article

C2 - 14595750

SN - 0022-3417

VL - 201

SP - 389

EP - 394

JO - Journal of Pathology

JF - Journal of Pathology

IS - 3

ER -

MSI-low, a real phenomenon which varies in frequency among cancer types

Abstract

Keywords

UN SDGs

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