Multi-azole resistance in Aspergillus fumigatus

Susan J. Howard, Ian Webster, Caroline B. Moore, Rebecca E. Gardiner, Steven Park, David S. Perlin, David W. Denning

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14α-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months. © 2006 Elsevier B.V. and the International Society of Chemotherapy.
    Original languageEnglish
    Pages (from-to)450-453
    Number of pages3
    JournalInternational Journal of Antimicrobial Agents
    Volume28
    Issue number5
    DOIs
    Publication statusPublished - Nov 2006

    Keywords

    • Aspergillosis
    • Aspergillus
    • Azole
    • cyp51A
    • Itraconazole
    • Resistance

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