Multi-echo functional MRS Glutamate measurements in visual cortex at 3T

Polina Emeliyanova; Laura Parkes; Steve R Williams; Caroline Lea-Carnall

Multi-echo functional MRS Glutamate measurements in visual cortex at 3T

Polina Emeliyanova, Laura Parkes, Steve R Williams, Caroline Lea-Carnall

Research output: Contribution to conference › Abstract › peer-review

Abstract

fMRS studies have shown dynamic change in glutamate (Glu) concentrations during visual stimulation. Here, we examine the effect of TE from 9.3-280ms on the signal during fMRS acquisition and whether T2 relaxation parameters change during a visual task compared to rest. We observed a short Glu T2-compartment between 2.5-4.5ms arising from 48% (rest) and 16% (active) of the total signal with significant increase in Glu signal at TE =140ms during stimulation. These preliminary results indicate bi-exponential decay of Glu in the visual cortex at 3T encouraging future work with more robust fMRS paradigms.

Original language	English
Publication status	Published - 1 Mar 2023
Event	2023 ISMRM & ISMRT Annual Meeting & Exhibition - Metro Toronto Convention Centre, Toronto, Canada Duration: 3 Jun 2023 → 8 Jun 2023

Conference

Conference	2023 ISMRM & ISMRT Annual Meeting & Exhibition
Country/Territory	Canada
City	Toronto
Period	3/06/23 → 8/06/23

Keywords

data acquisition
spectroscopy
functional MRS
multi-echo MRS
3T
glutamate
creatine (Cr)
N-Asetyl-Aspartate (NAA)

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https://archive.ismrm.org/2023/0356.html

Cite this

@conference{37d1744d441f40bc8f78c276e50efe20,

title = "Multi-echo functional MRS Glutamate measurements in visual cortex at 3T",

abstract = "fMRS studies have shown dynamic change in glutamate (Glu) concentrations during visual stimulation. Here, we examine the effect of TE from 9.3-280ms on the signal during fMRS acquisition and whether T2 relaxation parameters change during a visual task compared to rest. We observed a short Glu T2-compartment between 2.5-4.5ms arising from 48% (rest) and 16% (active) of the total signal with significant increase in Glu signal at TE =140ms during stimulation. These preliminary results indicate bi-exponential decay of Glu in the visual cortex at 3T encouraging future work with more robust fMRS paradigms.",

keywords = "data acquisition, spectroscopy, functional MRS, multi-echo MRS, 3T, glutamate, creatine (Cr), N-Asetyl-Aspartate (NAA)",

author = "Polina Emeliyanova and Laura Parkes and Williams, {Steve R} and Caroline Lea-Carnall",

year = "2023",

month = mar,

day = "1",

language = "English",

note = "2023 ISMRM & ISMRT Annual Meeting & Exhibition ; Conference date: 03-06-2023 Through 08-06-2023",

}

TY - CONF

T1 - Multi-echo functional MRS Glutamate measurements in visual cortex at 3T

AU - Emeliyanova, Polina

AU - Parkes, Laura

AU - Williams, Steve R

AU - Lea-Carnall, Caroline

PY - 2023/3/1

Y1 - 2023/3/1

N2 - fMRS studies have shown dynamic change in glutamate (Glu) concentrations during visual stimulation. Here, we examine the effect of TE from 9.3-280ms on the signal during fMRS acquisition and whether T2 relaxation parameters change during a visual task compared to rest. We observed a short Glu T2-compartment between 2.5-4.5ms arising from 48% (rest) and 16% (active) of the total signal with significant increase in Glu signal at TE =140ms during stimulation. These preliminary results indicate bi-exponential decay of Glu in the visual cortex at 3T encouraging future work with more robust fMRS paradigms.

AB - fMRS studies have shown dynamic change in glutamate (Glu) concentrations during visual stimulation. Here, we examine the effect of TE from 9.3-280ms on the signal during fMRS acquisition and whether T2 relaxation parameters change during a visual task compared to rest. We observed a short Glu T2-compartment between 2.5-4.5ms arising from 48% (rest) and 16% (active) of the total signal with significant increase in Glu signal at TE =140ms during stimulation. These preliminary results indicate bi-exponential decay of Glu in the visual cortex at 3T encouraging future work with more robust fMRS paradigms.

KW - data acquisition

KW - spectroscopy

KW - functional MRS

KW - multi-echo MRS

KW - 3T

KW - glutamate

KW - creatine (Cr)

KW - N-Asetyl-Aspartate (NAA)

M3 - Abstract

T2 - 2023 ISMRM & ISMRT Annual Meeting & Exhibition

Y2 - 3 June 2023 through 8 June 2023

ER -

Multi-echo functional MRS Glutamate measurements in visual cortex at 3T

Abstract

Conference

Keywords

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