Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Wasco Wruck; Karl Kashofer; Samrina Rehman; Andriani Daskalaki; Daniela Berg; Ewa Gralka; Justyna Jozefczuk; Katharina Drews; Vikash Pandey; Christian Regenbrecht; Christoph Wierling; Paola Turano; Ulrike Korf; Kurt Zatloukal; Hans Lehrach; Hans V Westerhoff; James Adjaye

doi:10.1038/sdata.2015.68

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Wasco Wruck, Karl Kashofer, Samrina Rehman, Andriani Daskalaki, Daniela Berg, Ewa Gralka, Justyna Jozefczuk, Katharina Drews, Vikash Pandey, Christian Regenbrecht, Christoph Wierling, Paola Turano, Ulrike Korf, Kurt Zatloukal, Hans Lehrach, Hans V Westerhoff, James Adjaye

Research output: Contribution to journal › Article › peer-review

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study explores the early steatosis stage of NAFLD with the aim of identifying molecular mechanisms underlying the etiology of NAFLD. We analyzed liver biopsies and serum samples from patients with high- and low-grade steatosis (also pre-disease states) employing transcriptomics, ELISA-based serum protein analyses and metabolomics. Here, we provide a detailed description of the various related datasets produced in the course of this study. These datasets may help other researchers find new clues for the etiology of NAFLD and the mechanisms underlying its progression to more severe disease states.

Original language	English
Pages (from-to)	150068
Journal	Scientific Data
Volume	2
DOIs	https://doi.org/10.1038/sdata.2015.68
Publication status	Published - 8 Dec 2015

Keywords

Apolipoprotein C-III
Biopsy
Chondroitin Sulfate Proteoglycans
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Lectins, C-Type
Lipase
Liver
Membrane Proteins
Nerve Tissue Proteins
Non-alcoholic Fatty Liver Disease
Polymorphism, Single Nucleotide
Protein Phosphatase 1
Dataset
Journal Article
Research Support, Non-U.S. Gov't

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sdata.2015.68

http://www.nature.com/articles/sdata201568

Cite this

Wruck, W., Kashofer, K., Rehman, S., Daskalaki, A., Berg, D., Gralka, E., Jozefczuk, J., Drews, K., Pandey, V., Regenbrecht, C., Wierling, C., Turano, P., Korf, U., Zatloukal, K., Lehrach, H., Westerhoff, H. V., & Adjaye, J. (2015). Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. Scientific Data, 2, 150068. https://doi.org/10.1038/sdata.2015.68

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title = "Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes",

abstract = "Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study explores the early steatosis stage of NAFLD with the aim of identifying molecular mechanisms underlying the etiology of NAFLD. We analyzed liver biopsies and serum samples from patients with high- and low-grade steatosis (also pre-disease states) employing transcriptomics, ELISA-based serum protein analyses and metabolomics. Here, we provide a detailed description of the various related datasets produced in the course of this study. These datasets may help other researchers find new clues for the etiology of NAFLD and the mechanisms underlying its progression to more severe disease states.",

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author = "Wasco Wruck and Karl Kashofer and Samrina Rehman and Andriani Daskalaki and Daniela Berg and Ewa Gralka and Justyna Jozefczuk and Katharina Drews and Vikash Pandey and Christian Regenbrecht and Christoph Wierling and Paola Turano and Ulrike Korf and Kurt Zatloukal and Hans Lehrach and Westerhoff, {Hans V} and James Adjaye",

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Wruck, W, Kashofer, K, Rehman, S, Daskalaki, A, Berg, D, Gralka, E, Jozefczuk, J, Drews, K, Pandey, V, Regenbrecht, C, Wierling, C, Turano, P, Korf, U, Zatloukal, K, Lehrach, H, Westerhoff, HV & Adjaye, J 2015, 'Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes', Scientific Data, vol. 2, pp. 150068. https://doi.org/10.1038/sdata.2015.68

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T1 - Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

AU - Wruck, Wasco

AU - Kashofer, Karl

AU - Rehman, Samrina

AU - Daskalaki, Andriani

AU - Berg, Daniela

AU - Gralka, Ewa

AU - Jozefczuk, Justyna

AU - Drews, Katharina

AU - Pandey, Vikash

AU - Regenbrecht, Christian

AU - Wierling, Christoph

AU - Turano, Paola

AU - Korf, Ulrike

AU - Zatloukal, Kurt

AU - Lehrach, Hans

AU - Westerhoff, Hans V

AU - Adjaye, James

PY - 2015/12/8

Y1 - 2015/12/8

N2 - Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study explores the early steatosis stage of NAFLD with the aim of identifying molecular mechanisms underlying the etiology of NAFLD. We analyzed liver biopsies and serum samples from patients with high- and low-grade steatosis (also pre-disease states) employing transcriptomics, ELISA-based serum protein analyses and metabolomics. Here, we provide a detailed description of the various related datasets produced in the course of this study. These datasets may help other researchers find new clues for the etiology of NAFLD and the mechanisms underlying its progression to more severe disease states.

AB - Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study explores the early steatosis stage of NAFLD with the aim of identifying molecular mechanisms underlying the etiology of NAFLD. We analyzed liver biopsies and serum samples from patients with high- and low-grade steatosis (also pre-disease states) employing transcriptomics, ELISA-based serum protein analyses and metabolomics. Here, we provide a detailed description of the various related datasets produced in the course of this study. These datasets may help other researchers find new clues for the etiology of NAFLD and the mechanisms underlying its progression to more severe disease states.

KW - Apolipoprotein C-III

KW - Biopsy

KW - Chondroitin Sulfate Proteoglycans

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Lectins, C-Type

KW - Lipase

KW - Liver

KW - Membrane Proteins

KW - Nerve Tissue Proteins

KW - Non-alcoholic Fatty Liver Disease

KW - Polymorphism, Single Nucleotide

KW - Protein Phosphatase 1

KW - Dataset

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/sdata.2015.68

DO - 10.1038/sdata.2015.68

M3 - Article

C2 - 26646939

SN - 2052-4463

VL - 2

SP - 150068

JO - Scientific Data

JF - Scientific Data

ER -

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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