TY - JOUR
T1 - Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in England
AU - Howell-Jones, R.
AU - Bailey, A.
AU - Beddows, S.
AU - Sargent, A.
AU - De Silva, N.
AU - Wilson, G.
AU - Anton, J.
AU - Nichols, T.
AU - Soldan, K.
AU - Kitchener, H.
PY - 2010/7/13
Y1 - 2010/7/13
N2 - Background:Knowledge of the prevalence of type-specific human papillomavirus (HPV) infections is necessary to predict the expected, and to monitor the actual, impact of HPV immunisation and to design effective screening strategies for vaccinated populations.Methods:Residual specimens of cervical cytology (N4719), CIN3CGIN and cervical cancer biopsies (N1515) were obtained from sites throughout England, anonymised and tested for HPV DNA using the Linear Array typing system (Roche).Results:The prevalence of HPV 16 andor 18 (with or without another high-risk (HR) type) was 76 in squamous cell carcinomas, 82 in adenoadenosquamous carcinomas and 63 and 91 in CIN3 and CGIN, respectively. Of all HR HPV-infected women undergoing cytology, non-vaccine HPV types only were found in over 60 of those with mild dyskaryosis or below, and in
AB - Background:Knowledge of the prevalence of type-specific human papillomavirus (HPV) infections is necessary to predict the expected, and to monitor the actual, impact of HPV immunisation and to design effective screening strategies for vaccinated populations.Methods:Residual specimens of cervical cytology (N4719), CIN3CGIN and cervical cancer biopsies (N1515) were obtained from sites throughout England, anonymised and tested for HPV DNA using the Linear Array typing system (Roche).Results:The prevalence of HPV 16 andor 18 (with or without another high-risk (HR) type) was 76 in squamous cell carcinomas, 82 in adenoadenosquamous carcinomas and 63 and 91 in CIN3 and CGIN, respectively. Of all HR HPV-infected women undergoing cytology, non-vaccine HPV types only were found in over 60 of those with mild dyskaryosis or below, and in
U2 - 10.1038/sj.bjc.6605747
DO - 10.1038/sj.bjc.6605747
M3 - Article
C2 - 20628396
SN - 0007-0920
VL - 103
SP - 209
EP - 216
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 2
ER -
