Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma

Jan Nico Bouwes Bavinck; Rachel E. Neale; Damiano Abeni; Sylvie Euvrard; Adele C. Green; Catherine A. Harwood; Maurits N C De Koning; Luigi Naldi; Ingo Nindl; Michael Pawlita; Herbert Pfister; Charlotte M. Proby; Wim G V Quint; Jan Ter Schegget; Tim Waterboer; Sönke Weissenborn; Mariet C W Feltkamp

doi:10.1158/0008-5472.CAN-10-0352

Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma

Jan Nico Bouwes Bavinck, Rachel E. Neale, Damiano Abeni, Sylvie Euvrard, Adele C. Green, Catherine A. Harwood, Maurits N C De Koning, Luigi Naldi, Ingo Nindl, Michael Pawlita, Herbert Pfister, Charlotte M. Proby, Wim G V Quint, Jan Ter Schegget, Tim Waterboer, Sönke Weissenborn, Mariet C W Feltkamp

Research output: Contribution to journal › Article › peer-review

Abstract

Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. ©2010 AACR.

Original language	English
Pages (from-to)	9777-9786
Number of pages	9
Journal	Cancer Research
Volume	70
Issue number	23
DOIs	https://doi.org/10.1158/0008-5472.CAN-10-0352
Publication status	Published - 1 Dec 2010

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Bouwes Bavinck, J. N., Neale, R. E., Abeni, D., Euvrard, S., Green, A. C., Harwood, C. A., De Koning, M. N. C., Naldi, L., Nindl, I., Pawlita, M., Pfister, H., Proby, C. M., Quint, W. G. V., Ter Schegget, J., Waterboer, T., Weissenborn, S., & Feltkamp, M. C. W. (2010). Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma. Cancer Research, 70(23), 9777-9786. https://doi.org/10.1158/0008-5472.CAN-10-0352

@article{a0182a33ae254b749a08a3ceebee154e,

title = "Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma",

abstract = "Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. {\textcopyright}2010 AACR.",

author = "{Bouwes Bavinck}, {Jan Nico} and Neale, {Rachel E.} and Damiano Abeni and Sylvie Euvrard and Green, {Adele C.} and Harwood, {Catherine A.} and {De Koning}, {Maurits N C} and Luigi Naldi and Ingo Nindl and Michael Pawlita and Herbert Pfister and Proby, {Charlotte M.} and Quint, {Wim G V} and {Ter Schegget}, Jan and Tim Waterboer and S{\"o}nke Weissenborn and Feltkamp, {Mariet C W}",

year = "2010",

month = dec,

day = "1",

doi = "10.1158/0008-5472.CAN-10-0352",

language = "English",

volume = "70",

pages = "9777--9786",

journal = "Cancer Research",

issn = "1538-7445",

publisher = "American Association for Cancer Research",

number = "23",

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Bouwes Bavinck, JN, Neale, RE, Abeni, D, Euvrard, S, Green, AC, Harwood, CA, De Koning, MNC, Naldi, L, Nindl, I, Pawlita, M, Pfister, H, Proby, CM, Quint, WGV, Ter Schegget, J, Waterboer, T, Weissenborn, S & Feltkamp, MCW 2010, 'Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma', Cancer Research, vol. 70, no. 23, pp. 9777-9786. https://doi.org/10.1158/0008-5472.CAN-10-0352

TY - JOUR

T1 - Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma

AU - Bouwes Bavinck, Jan Nico

AU - Neale, Rachel E.

AU - Abeni, Damiano

AU - Euvrard, Sylvie

AU - Green, Adele C.

AU - Harwood, Catherine A.

AU - De Koning, Maurits N C

AU - Naldi, Luigi

AU - Nindl, Ingo

AU - Pawlita, Michael

AU - Pfister, Herbert

AU - Proby, Charlotte M.

AU - Quint, Wim G V

AU - Ter Schegget, Jan

AU - Waterboer, Tim

AU - Weissenborn, Sönke

AU - Feltkamp, Mariet C W

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. ©2010 AACR.

AB - Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. ©2010 AACR.

U2 - 10.1158/0008-5472.CAN-10-0352

DO - 10.1158/0008-5472.CAN-10-0352

M3 - Article

C2 - 21098702

SN - 1538-7445

VL - 70

SP - 9777

EP - 9786

JO - Cancer Research

JF - Cancer Research

IS - 23

ER -

Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma

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