Multimodal Evaluation of Presumed Tuberculous Serpiginous-Like Choroiditis

Haoyu Wang, Shi Zhuan Tan, Tariq Aslam, Nicholas P. Jones, Laura R. Steeples

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Abstract

Purpose: To evaluate multimodal imaging findings in longitudinal follow-up of a patient with presumed tuberculous serpiginous-like choroiditis (TB-SLC).

Method: We evaluated multimodal imaging in a 62-year-old male with TB-SLC. Correlation between optical coherence tomography angiography (OCTA), swept-source OCT (SS-OCT) and fundus autofluorescence (FAF) at defined disease stages and evolution of observed imaging descriptors during long-term follow-up has not been previously reported.

Results: OCTA of the active lesion demonstrated defined areas of choriocapillaris hypoperfusion, suggesting inflammatory vascular occlusive pathology. Over 9-month follow-up, OCTA illustrated sequential improvement in choriocapillaris flow, suggesting vascular remodeling. This correlated with progressive change in FAF signal and transition to diffuse hypoautofluorescence. SS-OCT demonstrated focal choroidal thickening and retinal pigment epithelium elevation in acute phase and resolution in time.

Conclusion: Multimodal imaging, particularly novel non-invasive technologies such as OCTA and SS-OCT, improves our understanding of the pathogenesis and evolution of disease in TB-SLC.
Original languageEnglish
Pages (from-to)1-5
JournalOcular Immunology and Inflammation
Early online date6 Aug 2018
DOIs
Publication statusPublished - 2018

Keywords

  • Fundus autofluorescence
  • multimodal imaging
  • optical coherence tomography angiography
  • presumed tuberculous serpiginous-like choroiditis
  • swept-source optical coherence tomography
  • uveitis

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