Multiple conductances of neuronal nicotinic acetylcholine receptors

C. A. Leech, D. B. Sattelle

    Research output: Contribution to journalArticlepeer-review


    In the presence of acetylcholine, cationic channels with three different conductances were recorded from neurones of the dissociated housefly (Musca domestica). Large conductance (80 pS) channels, resembling those that are abundant in reconstitution studies with a 65 kDa α-bungarotoxin affinity purified polypeptide, were detected in situ. The two larger conductance channels (80 pS; 32 pS) exhibited open and closed times that were best fitted by multiple exponential functions, indicating the presence of at least two open states. A third conductance (20 pS) showed brief, sparse openings and was least frequently observed. The 32 pS channel was the most common. © 1992.
    Original languageEnglish
    Pages (from-to)501-507
    Number of pages6
    Issue number5
    Publication statusPublished - May 1992


    • acetylcholine
    • conductances
    • housefly (Musca domestica)
    • nicotinic receptor


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