Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.

L.B Laudiero; L Aloe; R Levi-Montalcini; C Buttinelli; D Schitler; Silke Gillessen Sommer; U Otten

Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.

L.B Laudiero, L Aloe, R Levi-Montalcini, C Buttinelli, D Schitler, Silke Gillessen Sommer, U Otten

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.

Original language	English
Pages (from-to)	9-12
Journal	Neurosci Lett
Volume	147
Issue number	1
Publication status	Published - 23 Nov 1992

Cite this

@article{387121afb17f419699ca13b1b6954a2b,

title = "Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.",

abstract = "We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.",

author = "L.B Laudiero and L Aloe and R Levi-Montalcini and C Buttinelli and D Schitler and {Gillessen Sommer}, Silke and U Otten",

year = "1992",

month = nov,

day = "23",

language = "English",

volume = "147",

pages = "9--12",

journal = "Neurosci Lett",

issn = "1872-7972",

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T1 - Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.

AU - Laudiero, L.B

AU - Aloe, L

AU - Levi-Montalcini, R

AU - Buttinelli, C

AU - Schitler, D

AU - Gillessen Sommer, Silke

AU - Otten, U

PY - 1992/11/23

Y1 - 1992/11/23

N2 - We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.

AB - We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.

M3 - Review article

SN - 1872-7972

VL - 147

SP - 9

EP - 12

JO - Neurosci Lett

JF - Neurosci Lett

IS - 1

ER -

Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.

Abstract

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