Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Neazar E Baghdadi, Benjamin P Burke, Tahani Alresheedi, Shubhanchi Nigam, Abdu Saeed, Farooq Almutairi, Juozas Domarkas, Abid Khan, Stephen J Archibald

Research output: Contribution to journalArticlepeer-review


The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

Original languageEnglish
JournalDalton Transactions
Publication statusPublished - 27 Jan 2021


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