Multivariate AB-BA crossover trial

Luis Rodriguez, Luis A. Rodríguez-Carvajal, Geoff H. Freeman

    Research output: Contribution to journalArticlepeer-review


    One way to analyze the AB-BA crossover trial with multivariate response is proposed. The multivariate model is given and the assumptions discussed. Two possibilities for the treatment effects hypothesis are considered. The statistical tests include the use of Hotelling's T2 statistic, and a transformation equivalent to that of Jones and Kenward for the univariate case. Data from a nutrition experiment in Mexico illustrate the method. The multiple comparisons are carried out using Bonferroni intervals and the validity of the assumptions is explored. The main conclusions include the finding that some of the assumptions are not a requirement for the multivariate analysis; however, the sample sizes are important.
    Original languageEnglish
    Pages (from-to)393-403
    Number of pages10
    JournalJournal of Applied Statistics
    Issue number3
    Publication statusPublished - 1999


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