Multivesicular bodies: co-ordinated progression to maturity

Philip G. Woodman; Clare E. Futter

doi:10.1016/j.ceb.2008.04.001

Multivesicular bodies: co-ordinated progression to maturity

Research output: Contribution to journal › Article › peer-review

Abstract

Multivesicular endosomes/bodies (MVBs) sort endocytosed proteins to different destinations. Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions. MVBs move to the cell centre during this maturation process and, when all recycling proteins have been removed, fuse with lysosomes. Recent advances have identified endosomal-sorting complex required for transport (ESCRT)-dependent and ESCRT-independent pathways in intralumenal vesicle formation and mechanisms for sorting recycling cargo into tubules. Cytoskeletal motors, through interactions with these machineries and by regulating MVB movement, help to co-ordinate events leading to a mature, fusion-competent MVB. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	408-414
Number of pages	6
Journal	Current opinion in cell biology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.ceb.2008.04.001
Publication status	Published - Aug 2008

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title = "Multivesicular bodies: co-ordinated progression to maturity",

abstract = "Multivesicular endosomes/bodies (MVBs) sort endocytosed proteins to different destinations. Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions. MVBs move to the cell centre during this maturation process and, when all recycling proteins have been removed, fuse with lysosomes. Recent advances have identified endosomal-sorting complex required for transport (ESCRT)-dependent and ESCRT-independent pathways in intralumenal vesicle formation and mechanisms for sorting recycling cargo into tubules. Cytoskeletal motors, through interactions with these machineries and by regulating MVB movement, help to co-ordinate events leading to a mature, fusion-competent MVB. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

author = "Woodman, {Philip G.} and Futter, {Clare E.}",

year = "2008",

month = aug,

doi = "10.1016/j.ceb.2008.04.001",

language = "English",

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AU - Futter, Clare E.

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AB - Multivesicular endosomes/bodies (MVBs) sort endocytosed proteins to different destinations. Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions. MVBs move to the cell centre during this maturation process and, when all recycling proteins have been removed, fuse with lysosomes. Recent advances have identified endosomal-sorting complex required for transport (ESCRT)-dependent and ESCRT-independent pathways in intralumenal vesicle formation and mechanisms for sorting recycling cargo into tubules. Cytoskeletal motors, through interactions with these machineries and by regulating MVB movement, help to co-ordinate events leading to a mature, fusion-competent MVB. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.ceb.2008.04.001

DO - 10.1016/j.ceb.2008.04.001

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SP - 408

EP - 414

JO - Current opinion in cell biology

JF - Current opinion in cell biology

IS - 4

ER -

Multivesicular bodies: co-ordinated progression to maturity

Abstract

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