Mutant p53 in cancer: New functions and therapeutic opportunities

Patricia A J Muller, Karen H. Vousden

Research output: Contribution to journalReview articlepeer-review

Abstract

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

Original languageEnglish
Pages (from-to)304-317
Number of pages14
JournalCancer Cell
Volume25
Issue number3
DOIs
Publication statusPublished - 17 Mar 2014

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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