Mutant p53 in cancer: New functions and therapeutic opportunities

Patricia A J Muller; Karen H. Vousden

doi:10.1016/j.ccr.2014.01.021

Mutant p53 in cancer: New functions and therapeutic opportunities

Patricia A J Muller^*, Karen H. Vousden

^*Corresponding author for this work

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

Original language	English
Pages (from-to)	304-317
Number of pages	14
Journal	Cancer Cell
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.ccr.2014.01.021
Publication status	Published - 17 Mar 2014

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2014.01.021

Cite this

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title = "Mutant p53 in cancer: New functions and therapeutic opportunities",

abstract = "Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.",

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AB - Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

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Mutant p53 in cancer: New functions and therapeutic opportunities

Abstract

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UN SDGs

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