Mutants of Aspergillus nidulans with increased resistance to the alkylating agent, N-methyl-N′-nitro-N-nitrosoguanidine

P. Hooley, S. G. Shawcross, P. Strike

Research output: Contribution to journalArticlepeer-review

Abstract

The isolation and characterisation of mutants of Aspergillus nidulans showing resistance to MNNG is described. Such isolates were stable through prolonged subculture in the absence of the selective agent, and resistance segregated as an allele of a single gene in meiotic and mitotic analysis. MNNG-resistant strains showed an increase in resistance to EMS and UV irradiation but no cross-resistance to MMS was detected. Possible mechanisms of resistance to alkylating agents are discussed.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalMutation Research DNA Repair Reports
Volume193
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • Alkylating agents,resistance to
  • Aspergillus nidulans
  • DNA repair
  • MNNG resistance

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