Abstract
The frequency of lymphocites with mutations at genes of T-cell receptor (TCR) is determined in 165 persons exposed to ionizing radiation 16-40 years after the influence. Depending on a type of irradiation and time, elapsed from the moment of exposure, all inspected persons were divided into 3 groups: the analysis performed 16-40 years after acute irradiation; 9-13 years after acute irradiation; 9-13 years after prolonged irradiation. The persons with elevated frequencies of TCR-mutant cells were detected in all three groups. In the first group they have compounded 36% of persons inspected, in the second - 25%, in the third - 15%. The percentage of persons with elevated frequencies of mutant cells in all groups was significantly higher than in control groups. Taking into account fast enough elimination of radiation-induced TCR-mutant cells it is possible to suspect, that the cause of elevated frequency of mutant cells in the part of the persons can be genome instability.
| Original language | English |
|---|---|
| Title of host publication | Radiatsionnaya Biologiya. Radioekologiya|Radiats Biol Radioekol |
| Place of Publication | London and New York |
| Publisher | Routledge |
| Pages | 624-627 |
| Number of pages | 3 |
| Volume | 42 |
| Publication status | Published - 2002 |