Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets

Sean A. Hudson; Kirsty J. McLean; Andrew W. Munro; Chris Abell

doi:10.1042/BST20120062

Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets

Sean A. Hudson, Kirsty J. McLean, Andrew W. Munro, Chris Abell

Research output: Contribution to journal › Article › peer-review

Abstract

TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability. ©The Authors Journal compilation ©2012 Biochemical Society.

Original language	English
Pages (from-to)	573-579
Number of pages	6
Journal	Biochemical Society Transactions
Volume	40
Issue number	3
DOIs	https://doi.org/10.1042/BST20120062
Publication status	Published - Jun 2012

Keywords

Cytochrome P450
Drug discovery
Fragment-based drug discovery
High-throughput screening (HTS)
Mycobacterium tuberculosis
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/BST20120062

http://www.biochemsoctrans.org/bst/040/0573/0400573.pdf

Cite this

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title = "Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets",

abstract = "TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability. {\textcopyright}The Authors Journal compilation {\textcopyright}2012 Biochemical Society.",

keywords = "Cytochrome P450, Drug discovery, Fragment-based drug discovery, High-throughput screening (HTS), Mycobacterium tuberculosis, Tuberculosis",

author = "Hudson, {Sean A.} and McLean, {Kirsty J.} and Munro, {Andrew W.} and Chris Abell",

year = "2012",

month = jun,

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language = "English",

volume = "40",

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journal = "Biochemical Society Transactions",

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T1 - Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets

AU - Hudson, Sean A.

AU - McLean, Kirsty J.

AU - Munro, Andrew W.

AU - Abell, Chris

PY - 2012/6

Y1 - 2012/6

N2 - TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability. ©The Authors Journal compilation ©2012 Biochemical Society.

AB - TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability. ©The Authors Journal compilation ©2012 Biochemical Society.

KW - Cytochrome P450

KW - Drug discovery

KW - Fragment-based drug discovery

KW - High-throughput screening (HTS)

KW - Mycobacterium tuberculosis

KW - Tuberculosis

U2 - 10.1042/BST20120062

DO - 10.1042/BST20120062

M3 - Article

SN - 1470-8752

VL - 40

SP - 573

EP - 579

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 3

ER -

Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets

Abstract

Keywords

UN SDGs

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