Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

David E. Williams; Doralyn S. Dalisay; Fengling Li; James Amphlett; Wisanu Maneerat; Miguel Angel Garcia Chavez; Yan Alexander Wang; Teatulohi Matainaho; Wenyu Yu; Peter J. Brown; Cheryl H. Arrowsmith; Masoud Vedadi; Raymond J. Andersen

doi:10.1021/ol303416k

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

David E. Williams, Doralyn S. Dalisay, Fengling Li, James Amphlett, Wisanu Maneerat, Miguel Angel Garcia Chavez, Yan Alexander Wang, Teatulohi Matainaho, Wenyu Yu, Peter J. Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Raymond J. Andersen

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. © 2012 American Chemical Society.

Original language	English
Pages (from-to)	414-417
Number of pages	3
Journal	Organic Letters
Volume	15
Issue number	2
DOIs	https://doi.org/10.1021/ol303416k
Publication status	Published - 18 Jan 2013

Access to Document

10.1021/ol303416k

Cite this

Williams, D. E., Dalisay, D. S., Li, F., Amphlett, J., Maneerat, W., Chavez, M. A. G., Wang, Y. A., Matainaho, T., Yu, W., Brown, P. J., Arrowsmith, C. H., Vedadi, M., & Andersen, R. J. (2013). Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Organic Letters, 15(2), 414-417. https://doi.org/10.1021/ol303416k

@article{216aeabff4f64f74a93a05b56554b379,

title = "Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8",

abstract = "The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. {\textcopyright} 2012 American Chemical Society.",

author = "Williams, \{David E.\} and Dalisay, \{Doralyn S.\} and Fengling Li and James Amphlett and Wisanu Maneerat and Chavez, \{Miguel Angel Garcia\} and Wang, \{Yan Alexander\} and Teatulohi Matainaho and Wenyu Yu and Brown, \{Peter J.\} and Arrowsmith, \{Cheryl H.\} and Masoud Vedadi and Andersen, \{Raymond J.\}",

year = "2013",

month = jan,

day = "18",

doi = "10.1021/ol303416k",

language = "English",

volume = "15",

pages = "414--417",

journal = "Organic Letters",

issn = "1523-7052",

publisher = "American Chemical Society",

number = "2",

}

Williams, DE, Dalisay, DS, Li, F, Amphlett, J, Maneerat, W, Chavez, MAG, Wang, YA, Matainaho, T, Yu, W, Brown, PJ, Arrowsmith, CH, Vedadi, M & Andersen, RJ 2013, 'Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8', Organic Letters, vol. 15, no. 2, pp. 414-417. https://doi.org/10.1021/ol303416k

TY - JOUR

T1 - Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

AU - Williams, David E.

AU - Dalisay, Doralyn S.

AU - Li, Fengling

AU - Amphlett, James

AU - Maneerat, Wisanu

AU - Chavez, Miguel Angel Garcia

AU - Wang, Yan Alexander

AU - Matainaho, Teatulohi

AU - Yu, Wenyu

AU - Brown, Peter J.

AU - Arrowsmith, Cheryl H.

AU - Vedadi, Masoud

AU - Andersen, Raymond J.

PY - 2013/1/18

Y1 - 2013/1/18

N2 - The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. © 2012 American Chemical Society.

AB - The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. © 2012 American Chemical Society.

UR - https://www.scopus.com/pages/publications/84872517716

U2 - 10.1021/ol303416k

DO - 10.1021/ol303416k

M3 - Article

SN - 1523-7052

VL - 15

SP - 414

EP - 417

JO - Organic Letters

JF - Organic Letters

IS - 2

ER -

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

Abstract

Access to Document

Other files and links

Fingerprint

Cite this