Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

David E. Williams; Doralyn S. Dalisay; Fengling Li; James Amphlett; Wisanu Maneerat; Miguel Angel Garcia Chavez; Yan Alexander Wang; Teatulohi Matainaho; Wenyu Yu; Peter J. Brown; Cheryl H. Arrowsmith; Masoud Vedadi; Raymond J. Andersen

doi:10.1021/ol303416k

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

David E. Williams
, Doralyn S. Dalisay
, Fengling Li
, James Amphlett
, Wisanu Maneerat
, Miguel Angel Garcia Chavez
, Yan Alexander Wang
, Teatulohi Matainaho
, Wenyu Yu
, Peter J. Brown
, Cheryl H. Arrowsmith
, Masoud Vedadi
, Raymond J. Andersen

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. © 2012 American Chemical Society.

Original language	English
Pages (from-to)	414-417
Number of pages	3
Journal	Organic Letters
Volume	15
Issue number	2
DOIs	https://doi.org/10.1021/ol303416k
Publication status	Published - 18 Jan 2013

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Williams, D. E., Dalisay, D. S., Li, F., Amphlett, J., Maneerat, W., Chavez, M. A. G., Wang, Y. A., Matainaho, T., Yu, W., Brown, P. J., Arrowsmith, C. H., Vedadi, M., & Andersen, R. J. (2013). Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Organic Letters, 15(2), 414-417. https://doi.org/10.1021/ol303416k

@article{216aeabff4f64f74a93a05b56554b379,

title = "Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8",

abstract = "The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. {\textcopyright} 2012 American Chemical Society.",

author = "Williams, \{David E.\} and Dalisay, \{Doralyn S.\} and Fengling Li and James Amphlett and Wisanu Maneerat and Chavez, \{Miguel Angel Garcia\} and Wang, \{Yan Alexander\} and Teatulohi Matainaho and Wenyu Yu and Brown, \{Peter J.\} and Arrowsmith, \{Cheryl H.\} and Masoud Vedadi and Andersen, \{Raymond J.\}",

year = "2013",

month = jan,

day = "18",

doi = "10.1021/ol303416k",

language = "English",

volume = "15",

pages = "414--417",

journal = "Organic Letters",

issn = "1523-7052",

publisher = "American Chemical Society",

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Williams, DE, Dalisay, DS, Li, F, Amphlett, J, Maneerat, W, Chavez, MAG, Wang, YA, Matainaho, T, Yu, W, Brown, PJ, Arrowsmith, CH, Vedadi, M & Andersen, RJ 2013, 'Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8', Organic Letters, vol. 15, no. 2, pp. 414-417. https://doi.org/10.1021/ol303416k

TY - JOUR

T1 - Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

AU - Williams, David E.

AU - Dalisay, Doralyn S.

AU - Li, Fengling

AU - Amphlett, James

AU - Maneerat, Wisanu

AU - Chavez, Miguel Angel Garcia

AU - Wang, Yan Alexander

AU - Matainaho, Teatulohi

AU - Yu, Wenyu

AU - Brown, Peter J.

AU - Arrowsmith, Cheryl H.

AU - Vedadi, Masoud

AU - Andersen, Raymond J.

PY - 2013/1/18

Y1 - 2013/1/18

N2 - The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. © 2012 American Chemical Society.

AB - The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data. © 2012 American Chemical Society.

U2 - 10.1021/ol303416k

DO - 10.1021/ol303416k

M3 - Article

SN - 1523-7052

VL - 15

SP - 414

EP - 417

JO - Organic Letters

JF - Organic Letters

IS - 2

ER -

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

Abstract

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