Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome

Lois Gardner, Kostas Kostarelos, Parag Mallick, Caroline Dive, Marilena Hadjidemetriou (Corresponding)

Research output: Contribution to journalArticlepeer-review


Over the past decade, the development of ‘simple’ blood tests that enable cancer screening, diagnosis or monitoring and facilitate the design of personalized therapies without the need for invasive tumour biopsy sampling has been a core ambition in cancer research. Data emerging from ongoing biomarker development efforts indicate that multiple markers, used individually or as part of a multimodal panel, are required to enhance the sensitivity and specificity of assays for early stage cancer detection. The discovery of cancer-associated molecular alterations that are reflected in blood at multiple dimensions (genome, epigenome, transcriptome, proteome and metabolome) and integration of the resultant multi-omics data have the potential to uncover novel biomarkers as well as to further elucidate the underlying molecular pathways. Herein, we review key advances in multi-omics liquid biopsy approaches and introduce the ‘nano-omics’ paradigm: the development and utilization of nanotechnology tools for the enrichment and subsequent omics analysis of the blood-circulating cancerome.

Original languageEnglish
Pages (from-to)551-561
Number of pages11
JournalNature Reviews. Clinical Oncology
Issue number8
Early online date23 Jun 2022
Publication statusPublished - 1 Aug 2022

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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