Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma

I. Kimber; M. Moore; A. Howell; M. J S Wilkinson

doi:10.1007/BF00199459

Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma

I. Kimber, M. Moore, A. Howell, M. J S Wilkinson

Research output: Contribution to journal › Article › peer-review

Abstract

Lymphocytes isolated from axillary nodes draining breast carcinoma possess variable natural cytotoxic capacity. Augmentation of lymph node cell (LNC) cytotoxicity by interferon (IFN) is also variable, with only some populations displaying potentiated lysis following exposure to either IFN-α or gene-cloned IFN-α2. Where present the IFN-induced augmentation of LNC cytotoxicity was invariably weaker than that observed following similar treatment of autochthonous peripheral blood mononuclear cells (PBMC). Irrespective of their responsiveness to IFN the cytotoxic activity of all LNC preparations examined was significantly increased following pre-incubation with either staphylococcal enterotoxin A (SEA) or factors elaborated by lectin-pulsed allogeneic LNC. The induction or amplification of LNC-mediated natural cytotoxicity by lymphokines may provide a local potentiation of natural immune function at the host : tumour interface. © 1983 Springer-Verlag GmbH & Co KG.

Original language	English
Pages (from-to)	32-38
Number of pages	6
Journal	Cancer Immunology, Immunotherapy
Volume	15
Issue number	1
DOIs	https://doi.org/10.1007/BF00199459
Publication status	Published - Apr 1983

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title = "Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma",

abstract = "Lymphocytes isolated from axillary nodes draining breast carcinoma possess variable natural cytotoxic capacity. Augmentation of lymph node cell (LNC) cytotoxicity by interferon (IFN) is also variable, with only some populations displaying potentiated lysis following exposure to either IFN-α or gene-cloned IFN-α2. Where present the IFN-induced augmentation of LNC cytotoxicity was invariably weaker than that observed following similar treatment of autochthonous peripheral blood mononuclear cells (PBMC). Irrespective of their responsiveness to IFN the cytotoxic activity of all LNC preparations examined was significantly increased following pre-incubation with either staphylococcal enterotoxin A (SEA) or factors elaborated by lectin-pulsed allogeneic LNC. The induction or amplification of LNC-mediated natural cytotoxicity by lymphokines may provide a local potentiation of natural immune function at the host : tumour interface. {\textcopyright} 1983 Springer-Verlag GmbH & Co KG.",

author = "I. Kimber and M. Moore and A. Howell and Wilkinson, {M. J S}",

year = "1983",

month = apr,

doi = "10.1007/BF00199459",

language = "English",

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T1 - Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma

AU - Kimber, I.

AU - Moore, M.

AU - Howell, A.

AU - Wilkinson, M. J S

PY - 1983/4

Y1 - 1983/4

N2 - Lymphocytes isolated from axillary nodes draining breast carcinoma possess variable natural cytotoxic capacity. Augmentation of lymph node cell (LNC) cytotoxicity by interferon (IFN) is also variable, with only some populations displaying potentiated lysis following exposure to either IFN-α or gene-cloned IFN-α2. Where present the IFN-induced augmentation of LNC cytotoxicity was invariably weaker than that observed following similar treatment of autochthonous peripheral blood mononuclear cells (PBMC). Irrespective of their responsiveness to IFN the cytotoxic activity of all LNC preparations examined was significantly increased following pre-incubation with either staphylococcal enterotoxin A (SEA) or factors elaborated by lectin-pulsed allogeneic LNC. The induction or amplification of LNC-mediated natural cytotoxicity by lymphokines may provide a local potentiation of natural immune function at the host : tumour interface. © 1983 Springer-Verlag GmbH & Co KG.

AB - Lymphocytes isolated from axillary nodes draining breast carcinoma possess variable natural cytotoxic capacity. Augmentation of lymph node cell (LNC) cytotoxicity by interferon (IFN) is also variable, with only some populations displaying potentiated lysis following exposure to either IFN-α or gene-cloned IFN-α2. Where present the IFN-induced augmentation of LNC cytotoxicity was invariably weaker than that observed following similar treatment of autochthonous peripheral blood mononuclear cells (PBMC). Irrespective of their responsiveness to IFN the cytotoxic activity of all LNC preparations examined was significantly increased following pre-incubation with either staphylococcal enterotoxin A (SEA) or factors elaborated by lectin-pulsed allogeneic LNC. The induction or amplification of LNC-mediated natural cytotoxicity by lymphokines may provide a local potentiation of natural immune function at the host : tumour interface. © 1983 Springer-Verlag GmbH & Co KG.

U2 - 10.1007/BF00199459

DO - 10.1007/BF00199459

M3 - Article

C2 - 6553505

SN - 0340-7004

VL - 15

SP - 32

EP - 38

JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

IS - 1

ER -

Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma

Abstract

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