Natural history of mild and of moderate aortic stenosis-new insights from a large prospective european study

Christa Gohlke-Bärwolf, Jan Minners, Nikolaus Jander, Eva Gerdts, Kristian Wachtell, Simon Ray, Terje R. Pedersen

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Increased life expectancy has led to a higher prevalence of calcific aortic valve disease. Both ends of the disease spectrum-sclerosis of the aortic valve without hemodynamic obstruction and the late stage of aortic valve stenosis (AS)-have been associated with increased morbidity and mortality. This raises the question of the prognostic contribution of atherosclerotic diseases and other comorbidities as opposed to the hemodynamic effect of obstructive AS. Hence, the evaluation of asymptomatic patients with mild or moderate AS without comorbidities is of major interest. In the Simvastatin and Ezetimibe in Aortic Stenosis study, with the exception of hypertension, comorbidities were excluded, thus allowing an analysis of the effect of pure AS as well as the effect of hypertension on the progression and outcome of AS.We discuss the results that emerged from this large European prospective study and relate these to the published literature. © 2013 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)365-409
    Number of pages44
    JournalCurrent Problems in Cardiology
    Volume38
    Issue number9
    DOIs
    Publication statusPublished - Sep 2013

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