Abstract
Following heart-lung transplantation two of 21 patients who survived more than 100 days developed post-transplant lymphoproliferative disease. Both presented with localised ulcerative bronchitis documented at flexible bronchoscopy four months after transplantation. Histological examination showed necrosis with acute inflammation and ulceration. Case 2 demonstrated lymphoproliferative disease from biopsies subsequently taken at rigid bronchoscopy. Case 1 later developed lung nodules and a monoclonal high grade B cell non-Hodgkin's lymphoma was confirmed by an open lung biopsy. The bronchoscopic features described should alert clinicians to post-transplant lymphoproliferative disease as an underlying diagnosis and suggest that bronchus associated lymphoid tissue is the initial site for clonal proliferation in the disease.
Original language | English |
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Pages (from-to) | 205-207 |
Number of pages | 2 |
Journal | Thorax |
Volume | 50 |
Issue number | 2 |
Publication status | Published - 1995 |
Keywords
- Heart-lung transplantation
- Lymphoproliferative disease
- Ulcerative bronchitis