Necrotic, ulcerative bronchitis, the presenting feature of lymphoproliferative disease following heart-lung transplantation

J. J. Egan, P. S. Hasleton, N. Yonan, A. N. Rahman, A. K. Deiraniya, K. B A A Carroll Woodcock

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Following heart-lung transplantation two of 21 patients who survived more than 100 days developed post-transplant lymphoproliferative disease. Both presented with localised ulcerative bronchitis documented at flexible bronchoscopy four months after transplantation. Histological examination showed necrosis with acute inflammation and ulceration. Case 2 demonstrated lymphoproliferative disease from biopsies subsequently taken at rigid bronchoscopy. Case 1 later developed lung nodules and a monoclonal high grade B cell non-Hodgkin's lymphoma was confirmed by an open lung biopsy. The bronchoscopic features described should alert clinicians to post-transplant lymphoproliferative disease as an underlying diagnosis and suggest that bronchus associated lymphoid tissue is the initial site for clonal proliferation in the disease.
    Original languageEnglish
    Pages (from-to)205-207
    Number of pages2
    JournalThorax
    Volume50
    Issue number2
    Publication statusPublished - 1995

    Keywords

    • Heart-lung transplantation
    • Lymphoproliferative disease
    • Ulcerative bronchitis

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