Neprilysin, obesity and the metabolic syndrome.

K F Standeven; K Hess; A M Carter; G I Rice; P A Cordell; A J Balmforth; B Lu; D J Scott; A J Turner; N M Hooper; P J Grant

doi:10.1038/ijo.2010.227

Neprilysin, obesity and the metabolic syndrome.

K F Standeven, K Hess, A M Carter, G I Rice, P A Cordell, A J Balmforth, B Lu, D J Scott, A J Turner, N M Hooper, P J Grant

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318 healthy human subjects and in murine obesity, and investigated NEP production by adipocytes in-vitro. METHODS AND RESULTS: In 318 white European males, plasma NEP was elevated in the MetS and increased progressively with increasing MetS components. Plasma NEP activity correlated with insulin, homoeostasis model assessment and body mass index (BMI) in all subjects (P

Original language	English
Journal	International journal of obesity (2005)
Volume	35
Issue number	8
DOIs	https://doi.org/10.1038/ijo.2010.227
Publication status	Published - Aug 2011

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10.1038/ijo.2010.227

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title = "Neprilysin, obesity and the metabolic syndrome.",

abstract = "OBJECTIVE: Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318 healthy human subjects and in murine obesity, and investigated NEP production by adipocytes in-vitro. METHODS AND RESULTS: In 318 white European males, plasma NEP was elevated in the MetS and increased progressively with increasing MetS components. Plasma NEP activity correlated with insulin, homoeostasis model assessment and body mass index (BMI) in all subjects (P",

author = "Standeven, {K F} and K Hess and Carter, {A M} and Rice, {G I} and Cordell, {P A} and Balmforth, {A J} and B Lu and Scott, {D J} and Turner, {A J} and Hooper, {N M} and Grant, {P J}",

note = "PG/02/106/14434, British Heart Foundation, United KingdomPG/02/106/14434, British Heart Foundation, United Kingdom",

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AU - Standeven, K F

AU - Hess, K

AU - Carter, A M

AU - Rice, G I

AU - Cordell, P A

AU - Balmforth, A J

AU - Lu, B

AU - Scott, D J

AU - Turner, A J

AU - Hooper, N M

AU - Grant, P J

N1 - PG/02/106/14434, British Heart Foundation, United KingdomPG/02/106/14434, British Heart Foundation, United Kingdom

PY - 2011/8

Y1 - 2011/8

N2 - OBJECTIVE: Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318 healthy human subjects and in murine obesity, and investigated NEP production by adipocytes in-vitro. METHODS AND RESULTS: In 318 white European males, plasma NEP was elevated in the MetS and increased progressively with increasing MetS components. Plasma NEP activity correlated with insulin, homoeostasis model assessment and body mass index (BMI) in all subjects (P

AB - OBJECTIVE: Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318 healthy human subjects and in murine obesity, and investigated NEP production by adipocytes in-vitro. METHODS AND RESULTS: In 318 white European males, plasma NEP was elevated in the MetS and increased progressively with increasing MetS components. Plasma NEP activity correlated with insulin, homoeostasis model assessment and body mass index (BMI) in all subjects (P

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DO - 10.1038/ijo.2010.227

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SN - 1476-5497

VL - 35

JO - International journal of obesity (2005)

JF - International journal of obesity (2005)

IS - 8

ER -

Neprilysin, obesity and the metabolic syndrome.

Abstract

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