Nerve pathology in the type 1 diabetic dog: Effects of treatment with sulindac

David Walker, Irfan Siddique, Heather Anderson, Tom A. Gardiner, Desmond B. Archer, Andrew J M Boulton, Rayaz A. Malik

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The purpose of this study was to define pathological abnormalities in the peripheral nerve of a large animal model of long-duration type 1 diabetes and also to determine the effects of treatment with sulindac. Detailed morphometric studies were performed to define nerve fiber and endoneurial capillary pathology in 6 control dogs, 6 type 1 diabetic dogs treated with insulin, and 6 type 1 diabetic dogs treated with insulin and sulindac for 4 years. Myelinated fiber and regenerative cluster density showed a non-significant trend toward a reduction in diabetic compared to control animals, which was prevented by treatment with sulindac. Unmyelinated fiber density did not differ among groups. However, diabetic animals showed a non-significant trend toward an increase in axon diameter (p <0.07), with a shift of the size frequency distribution towards larger axons, which was not prevented by treatment with sulindac. Endoneurial capillary density and luminal area showed a non-significant trend toward an increase in diabetic animals, which was prevented with sulindac treatment. Endoneurial capillary basement membrane area was significantly increased (p <0.05) in diabetic animals, but was not prevented with sulindac treatment. We conclude that the type 1 diabetic dog demonstrates minor structural abnormalities in the nerve fibers and endoneurial capillaries of the sciatic nerve, and treatment with sulindac ameliorates some but not all of these abnormalities.
    Original languageEnglish
    Pages (from-to)219-226
    Number of pages7
    JournalJournal of the Peripheral Nervous System
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Endoneurial capillary
    • Morphometry
    • Nerve fiber
    • Neuropathy
    • Sulindac
    • Type 1 diabetes

    Fingerprint

    Dive into the research topics of 'Nerve pathology in the type 1 diabetic dog: Effects of treatment with sulindac'. Together they form a unique fingerprint.

    Cite this