NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy

G Ponirakis; M N Odriozola; S Odriozola; I N Petropoulos; S Azmi; H Fadavi; U Alam; O Asghar; A Marshall; A Miro; A Kheyami; A Al-Ahmar; M B Odriozola; A Odriozola; Rayaz Malik

doi:10.1016/j.diabres.2015.12.023

NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy

G Ponirakis, M N Odriozola, S Odriozola, I N Petropoulos, S Azmi, H Fadavi, U Alam, O Asghar, A Marshall, A Miro, A Kheyami, A Al-Ahmar, M B Odriozola, A Odriozola, Rayaz Malik

Research output: Contribution to journal › Article › peer-review

Abstract

AIMS: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy.

METHODS: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria.

RESULTS: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively.

CONCLUSIONS: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.

Original language	English
Pages (from-to)	101-7
Number of pages	7
Journal	Diabetes Research and Clinical Practice
Volume	113
DOIs	https://doi.org/10.1016/j.diabres.2015.12.023
Publication status	Published - Mar 2016

Keywords

Adult
Aged
Case-Control Studies
Diabetic Neuropathies
Diagnostic Techniques, Neurological
Female
Humans
Male
Middle Aged
Pain
Peripheral Nervous System Diseases
Reproducibility of Results
Vibration
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2015.12.023Licence: CC BY-NC-ND

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Ponirakis, G., Odriozola, M. N., Odriozola, S., Petropoulos, I. N., Azmi, S., Fadavi, H., Alam, U., Asghar, O., Marshall, A., Miro, A., Kheyami, A., Al-Ahmar, A., Odriozola, M. B., Odriozola, A., & Malik, R. (2016). NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy. Diabetes Research and Clinical Practice, 113, 101-7. https://doi.org/10.1016/j.diabres.2015.12.023

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title = "NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy",

abstract = "AIMS: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy.METHODS: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria.RESULTS: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively.CONCLUSIONS: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.",

keywords = "Adult, Aged, Case-Control Studies, Diabetic Neuropathies, Diagnostic Techniques, Neurological, Female, Humans, Male, Middle Aged, Pain, Peripheral Nervous System Diseases, Reproducibility of Results, Vibration, Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",

author = "G Ponirakis and Odriozola, {M N} and S Odriozola and Petropoulos, {I N} and S Azmi and H Fadavi and U Alam and O Asghar and A Marshall and A Miro and A Kheyami and A Al-Ahmar and Odriozola, {M B} and A Odriozola and Rayaz Malik",

year = "2016",

month = mar,

doi = "10.1016/j.diabres.2015.12.023",

language = "English",

volume = "113",

pages = "101--7",

journal = "Diabetes Research and Clinical Practice",

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Ponirakis, G, Odriozola, MN, Odriozola, S, Petropoulos, IN, Azmi, S, Fadavi, H, Alam, U, Asghar, O, Marshall, A, Miro, A, Kheyami, A, Al-Ahmar, A, Odriozola, MB, Odriozola, A & Malik, R 2016, 'NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy', Diabetes Research and Clinical Practice, vol. 113, pp. 101-7. https://doi.org/10.1016/j.diabres.2015.12.023

TY - JOUR

T1 - NerveCheck

T2 - An inexpensive quantitative sensory testing device for patients with diabetic neuropathy

AU - Ponirakis, G

AU - Odriozola, M N

AU - Odriozola, S

AU - Petropoulos, I N

AU - Azmi, S

AU - Fadavi, H

AU - Alam, U

AU - Asghar, O

AU - Marshall, A

AU - Miro, A

AU - Kheyami, A

AU - Al-Ahmar, A

AU - Odriozola, M B

AU - Odriozola, A

AU - Malik, Rayaz

PY - 2016/3

Y1 - 2016/3

N2 - AIMS: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy.METHODS: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria.RESULTS: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively.CONCLUSIONS: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.

AB - AIMS: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy.METHODS: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria.RESULTS: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively.CONCLUSIONS: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Diabetic Neuropathies

KW - Diagnostic Techniques, Neurological

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pain

KW - Peripheral Nervous System Diseases

KW - Reproducibility of Results

KW - Vibration

KW - Clinical Trial

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.diabres.2015.12.023

DO - 10.1016/j.diabres.2015.12.023

M3 - Article

C2 - 26830855

SN - 0168-8227

VL - 113

SP - 101

EP - 107

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

ER -

NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy

Abstract

Keywords

UN SDGs

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