Projects per year
Abstract
The early developmental phase is of critical importance for human health and disease later in life. To decipher the molecular mechanisms at play, current biomedical research is increasingly relying on large quantities of diverse omics data. The integration and interpretation of the different datasets pose a critical challenge towards the holistic understanding of the complex biological processes that are involved in early development. In this review, we outline the major transcriptomic and epigenetic processes and the respective datasets that are most relevant for studying the periconceptional period. We cover both basic data processing and analysis steps, as well as more advanced data integration methods. A particular focus is given to network-based methods. Finally, we review the medical applications of such integrative analyses
Original language | English |
---|---|
Article number | 764 |
Pages (from-to) | 764 |
Journal | Genes |
Volume | 13 |
Issue number | 5 |
Early online date | 26 Apr 2022 |
DOIs | |
Publication status | Published - 1 May 2022 |
Keywords
- DOHaD
- bioinformatics
- development
- epigenetics
- integrative
- networks
- transcriptomics
Fingerprint
Dive into the research topics of 'Network Approaches for Charting the Transcriptomic and Epigenetic Landscape of the Developmental Origins of Health and Disease'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Periconceptional Programming of Health Training Network.
Brison, D. (PI), Clayton, P. (CoI), Roberts, S. (CoI), Stevens, A. (CoI) & Ruane, P. (Grant contributor)
1/07/19 → 30/11/23
Project: Research