Network Approaches for Charting the Transcriptomic and Epigenetic Landscape of the Developmental Origins of Health and Disease

Salvo Danilo Lombardo, Ivan Fernando Wangsaputra, Jörg Menche, Adam Stevens

Research output: Contribution to journalArticlepeer-review

Abstract

The early developmental phase is of critical importance for human health and disease later in life. To decipher the molecular mechanisms at play, current biomedical research is increasingly relying on large quantities of diverse omics data. The integration and interpretation of the different datasets pose a critical challenge towards the holistic understanding of the complex biological processes that are involved in early development. In this review, we outline the major transcriptomic and epigenetic processes and the respective datasets that are most relevant for studying the periconceptional period. We cover both basic data processing and analysis steps, as well as more advanced data integration methods. A particular focus is given to network-based methods. Finally, we review the medical applications of such integrative analyses
Original languageEnglish
Article number764
Pages (from-to)764
JournalGenes
Volume13
Issue number5
Early online date26 Apr 2022
DOIs
Publication statusPublished - 1 May 2022

Keywords

  • DOHaD
  • bioinformatics
  • development
  • epigenetics
  • integrative
  • networks
  • transcriptomics

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