Neue TSH-Normalbereiche ab wann Therapieren?

Translated title of the contribution: New normal ranges for TSH: When to treat?

G. Brabant

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Subclinical forms of thyroid dysfunction rest purely on a biochemical definition. An increase or decrease of TSH compared to the laboratory norm defines the condition with thyroid hormone concentrations still within the norm. Recent population based large surveys defined a much narrower range of TSH levels between 0.3 and 2.5mU/l. As TSH determinations are subject to modulations due to endogenous and exogenous factors including substantial variations due to the laboratory methods, therapeutic intervention should not be considered when TSH levels are below the long accepted threshold of 4.55mU/l. This is supported by the lack of current data on an increased morbidity under these conditions. In contrast, subtle alterations of TSH in the context of subclinical hyperthyroidism are associated with a significantly higher risk particularly of atrial fibrillation. © 2009 Georg Thieme Verlag KG Stuttgart.
    Translated title of the contributionNew normal ranges for TSH: When to treat?
    Original languageGerman
    Pages (from-to)2510-2513
    Number of pages3
    JournalDeutsche Medizinische Wochenschrift
    Volume134
    Issue number49
    Publication statusPublished - 2009

    Keywords

    • Normal range
    • Subclinical thyroid dysfunction
    • TSH

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