Neural immunoregulation: Emerging roles for nerves in immune homeostasis and disease

James E G Downing; Jaleel A. Miyan

doi:10.1016/S0167-5699(00)01635-2

Neural immunoregulation: Emerging roles for nerves in immune homeostasis and disease

Research output: Contribution to journal › Article › peer-review

Abstract

In this review, James Downing and Jaleel Miyan outline emerging evidence for neural mechanisms that contribute to specific categories of host defence. Involvement of direct innervation in the adaptive control of immunological responses complements an established view of neuroendocrine-immune modulation. The challenge remains to understand the integrative and homeostatic functions of 'hardwiring' of peripheral immune effector sites, its bearing on disorder and potential for therapeutic modification.

Original language	English
Pages (from-to)	281-289
Number of pages	8
Journal	Immunology Today
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/S0167-5699(00)01635-2
Publication status	Published - 1 Jun 2000

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title = "Neural immunoregulation: Emerging roles for nerves in immune homeostasis and disease",

abstract = "In this review, James Downing and Jaleel Miyan outline emerging evidence for neural mechanisms that contribute to specific categories of host defence. Involvement of direct innervation in the adaptive control of immunological responses complements an established view of neuroendocrine-immune modulation. The challenge remains to understand the integrative and homeostatic functions of 'hardwiring' of peripheral immune effector sites, its bearing on disorder and potential for therapeutic modification.",

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AB - In this review, James Downing and Jaleel Miyan outline emerging evidence for neural mechanisms that contribute to specific categories of host defence. Involvement of direct innervation in the adaptive control of immunological responses complements an established view of neuroendocrine-immune modulation. The challenge remains to understand the integrative and homeostatic functions of 'hardwiring' of peripheral immune effector sites, its bearing on disorder and potential for therapeutic modification.

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Neural immunoregulation: Emerging roles for nerves in immune homeostasis and disease

Abstract

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