Neural mechanisms of opiate analgesia

J F Deakin, J O Dostrovsky

Research output: Contribution to journalArticlepeer-review


The analgesic action of morphine and other opiates has been known to man for a
long time , but it is only in the last five years that we have started to understand the
mechanism of action. This paper describes the exciting new discoveries relating to
the action of opiates in the brain and discusses current hypotheses on the role of
opiates in the modulation of pain sensation
Original languageEnglish
Pages (from-to)93-104
Number of pages12
JournalScience Progress (St. Albans, United Kingdom)
Issue number261
Publication statusPublished - 1979


  • Animals
  • Brain
  • Brain Chemistry
  • Brain Stem
  • Endorphins
  • Enkephalins
  • Humans
  • Morphine
  • Narcotics
  • Pain
  • Rats
  • Receptors, Opioid
  • Substance P
  • Journal Article


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