Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

R. P. Donn, A. Farhan, A. Stevans, A. Ramanan, W. E R Ollier, W. Thomson, M. Abinun, M. Becker, A. Bell, A. Craft, E. Crawley, J. David, H. Foster, J. Gardener-Medwin, J. Griffin, A. Hall, M. Hall, A. Herrick, P. Hollingworth, L. HoltS. Jones, G. Pountáin, C. Ryder, T. Southwood, I. Stewart, H. Venning, L. Wedderburn, P. Woo, S. Wyatt

    Research output: Contribution to journalArticlepeer-review


    Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. Results. None of the polymorphisms investigated showed any statistically significant associations with JIA. Conclusions. The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.
    Original languageEnglish
    Pages (from-to)930-936
    Number of pages6
    Issue number8
    Publication statusPublished - 2002


    • Juvenile idiopathic arthritis
    • Neuroendocrine
    • Polymorphisms


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