Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

R. P. Donn; A. Farhan; A. Stevans; A. Ramanan; W. E R Ollier; W. Thomson; M. Abinun; M. Becker; A. Bell; A. Craft; E. Crawley; J. David; H. Foster; J. Gardener-Medwin; J. Griffin; A. Hall; M. Hall; A. Herrick; P. Hollingworth; L. Holt; S. Jones; G. Pountáin; C. Ryder; T. Southwood; I. Stewart; H. Venning; L. Wedderburn; P. Woo; S. Wyatt

Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

R. P. Donn, A. Farhan, A. Stevans, A. Ramanan, W. E R Ollier, W. Thomson, M. Abinun, M. Becker, A. Bell, A. Craft, E. Crawley, J. David, H. Foster, J. Gardener-Medwin, J. Griffin, A. Hall, M. Hall, A. Herrick, P. Hollingworth, L. HoltS. Jones, G. Pountáin, C. Ryder, T. Southwood, I. Stewart, H. Venning, L. Wedderburn, P. Woo, S. Wyatt

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. Results. None of the polymorphisms investigated showed any statistically significant associations with JIA. Conclusions. The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

Original language	English
Pages (from-to)	930-936
Number of pages	6
Journal	Rheumatology
Volume	41
Issue number	8
Publication status	Published - 2002

Keywords

Juvenile idiopathic arthritis
Neuroendocrine
Polymorphisms

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Donn, R. P., Farhan, A., Stevans, A., Ramanan, A., Ollier, W. E. R., Thomson, W., Abinun, M., Becker, M., Bell, A., Craft, A., Crawley, E., David, J., Foster, H., Gardener-Medwin, J., Griffin, J., Hall, A., Hall, M., Herrick, A., Hollingworth, P., ... Wyatt, S. (2002). Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. Rheumatology, 41(8), 930-936.

@article{1afbdf7e348d469883afc54115ca8c72,

title = "Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis",

abstract = "Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. Results. None of the polymorphisms investigated showed any statistically significant associations with JIA. Conclusions. The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.",

keywords = "Juvenile idiopathic arthritis, Neuroendocrine, Polymorphisms",

author = "Donn, {R. P.} and A. Farhan and A. Stevans and A. Ramanan and Ollier, {W. E R} and W. Thomson and M. Abinun and M. Becker and A. Bell and A. Craft and E. Crawley and J. David and H. Foster and J. Gardener-Medwin and J. Griffin and A. Hall and M. Hall and A. Herrick and P. Hollingworth and L. Holt and S. Jones and G. Pount{\'a}in and C. Ryder and T. Southwood and I. Stewart and H. Venning and L. Wedderburn and P. Woo and S. Wyatt",

year = "2002",

language = "English",

volume = "41",

pages = "930--936",

journal = "Rheumatology",

issn = "1462-0332",

publisher = "Oxford University Press",

number = "8",

}

Donn, RP, Farhan, A, Stevans, A, Ramanan, A, Ollier, WER , Thomson, W, Abinun, M, Becker, M, Bell, A, Craft, A, Crawley, E, David, J, Foster, H, Gardener-Medwin, J, Griffin, J, Hall, A, Hall, M, Herrick, A, Hollingworth, P, Holt, L, Jones, S, Pountáin, G, Ryder, C, Southwood, T, Stewart, I, Venning, H, Wedderburn, L, Woo, P & Wyatt, S 2002, 'Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis', Rheumatology, vol. 41, no. 8, pp. 930-936.

TY - JOUR

T1 - Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

AU - Donn, R. P.

AU - Farhan, A.

AU - Stevans, A.

AU - Ramanan, A.

AU - Ollier, W. E R

AU - Thomson, W.

AU - Abinun, M.

AU - Becker, M.

AU - Bell, A.

AU - Craft, A.

AU - Crawley, E.

AU - David, J.

AU - Foster, H.

AU - Gardener-Medwin, J.

AU - Griffin, J.

AU - Hall, A.

AU - Hall, M.

AU - Herrick, A.

AU - Hollingworth, P.

AU - Holt, L.

AU - Jones, S.

AU - Pountáin, G.

AU - Ryder, C.

AU - Southwood, T.

AU - Stewart, I.

AU - Venning, H.

AU - Wedderburn, L.

AU - Woo, P.

AU - Wyatt, S.

PY - 2002

Y1 - 2002

N2 - Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. Results. None of the polymorphisms investigated showed any statistically significant associations with JIA. Conclusions. The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

AB - Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. Results. None of the polymorphisms investigated showed any statistically significant associations with JIA. Conclusions. The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

KW - Juvenile idiopathic arthritis

KW - Neuroendocrine

KW - Polymorphisms

M3 - Article

SN - 1462-0332

VL - 41

SP - 930

EP - 936

JO - Rheumatology

JF - Rheumatology

IS - 8

ER -

Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

Abstract

Keywords

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