Neuroglia: Functional paralysis and reactivity in Alzheimer’s disease and other neurodegenerative pathologies

Alexei Verkhratsky, Robert Zorec, J. J. Rodriguez, Vladimir Parpura

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The most notable finding in neurodegenerative diseases is the progressive death of neurones cells. Yet, neuroglial changes can precede and facilitate neuronal loss. This is perhaps expected because astroglial cells maintain the brain homoeostasis, and are responsible for defence and regeneration, so that their malfunction manifested as degeneration or asthenia together with reactivity contribute to pathophysiology. Neuroglia may represent a novel target for therapeutic intervention, be that prevention, slowing progression of or possibly curing neurodegenerative diseases.

Original languageEnglish
Title of host publicationNeurodegenerative Diseases
Subtitle of host publicationPathology, Mechanisms, and Potential Therapeutic Targets
EditorsPhilip Beart, Michael Robinson, Marcus Rattray, Nicholas J. Maragakis
PublisherSpringer Nature
Chapter17
Pages427-449
Number of pages23
ISBN (Electronic)978-3-319-57193-5
ISBN (Print)978-3-319-57191-1
DOIs
Publication statusPublished - 4 Jul 2017

Publication series

NameAdvances in Neurobiology
Volume15
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

Keywords

  • Alzheimer’s disease
  • Amyotrophic lateral sclerosis
  • Astroglia
  • Huntington disease
  • Neurodegenerative diseases
  • Neuroglia
  • Neurology

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