Neuroglia in ageing

Alexei Verkhratsky, Robert Zorec, Jose Julio Rodriguez-Arellano, Vladimir Parpura

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.

Original languageEnglish
Title of host publicationNeuroglia in Neurodegenerative Diseases
EditorsAlexei Verkhratsky, Margaret S Ho, Robert Zorec, Vladimir Parpura
PublisherSpringer Nature
Chapter8
Pages181-197
Number of pages17
Edition1
ISBN (Print)9789811399121
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1175
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Ageing
  • Astrocyte
  • Microglia
  • NG2 cells
  • Oligodendrocytes

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