Neuroglia in ageing

Alexei Verkhratsky; Robert Zorec; Jose Julio Rodriguez-Arellano; Vladimir Parpura

doi:10.1007/978-981-13-9913-8_8

Neuroglia in ageing

Alexei Verkhratsky^*, Robert Zorec, Jose Julio Rodriguez-Arellano, Vladimir Parpura

^*Corresponding author for this work

Division of Neuroscience

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Abstract

Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.

Original language	English
Title of host publication	Neuroglia in Neurodegenerative Diseases
Editors	Alexei Verkhratsky, Margaret S Ho, Robert Zorec, Vladimir Parpura
Publisher	Springer Nature
Chapter	8
Pages	181-197
Number of pages	17
Edition	1
ISBN (Print)	9789811399121
DOIs	https://doi.org/10.1007/978-981-13-9913-8_8
Publication status	Published - 1 Jan 2019

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1175
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Ageing
Astrocyte
Microglia
NG2 cells
Oligodendrocytes

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10.1007/978-981-13-9913-8_8

Cite this

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abstract = "Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.",

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Neuroglia in ageing. / Verkhratsky, Alexei; Zorec, Robert; Rodriguez-Arellano, Jose Julio et al.
Neuroglia in Neurodegenerative Diseases. ed. / Alexei Verkhratsky; Margaret S Ho; Robert Zorec; Vladimir Parpura. 1. ed. Springer Nature, 2019. p. 181-197 (Advances in Experimental Medicine and Biology; Vol. 1175).

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

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T1 - Neuroglia in ageing

AU - Verkhratsky, Alexei

AU - Zorec, Robert

AU - Rodriguez-Arellano, Jose Julio

AU - Parpura, Vladimir

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A2 - Parpura, Vladimir

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Neuroglia in ageing

Abstract

Publication series

Keywords

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