Neurohypophysial hormones and renal function in fish and mammals

J. M. Warne, K. E. Harding, R. J. Balment

    Research output: Contribution to journalArticlepeer-review


    The two major basic neurohypophysial peptides, arginine vasopressin (AVP) of mammals and arginine vasotocin (AVT) of all non-mammalian vertebrates, share common structure and major roles in regulating renal function. In this review the complexity of AVP actions within the mammalian kidney is discussed and comparisons are made with the emerging picture of AVT's renal effects in fish. It has become apparent that the antidiuretic action of the neurohypophysial hormones is an ancient phylogenetic phenomenon, although this is based upon reduced glomerular filtration in fish by comparison with predominant tubular effects in mammals. Nonetheless, there appears to be retention of AVP effects upon the functional heterogeneity of nephron populations in mammals. Preliminary evidence for the possible existence of V2-type (tubular) neurohypophysial hormone receptors in fish, implies possible AVT actions which parallel those in mammals on tubular ion transport. Further insight from recent mammalian tubule microperfusion studies suggests that in teleost fish both apical (tubular lumen) and basolateral (blood borne) AVT have the potential to modulate renal function, though this remains to be examined. © 2002 Elsevier Science Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)231-237
    Number of pages6
    JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
    Issue number1
    Publication statusPublished - 2002


    • Arginine vasopressin
    • Arginine vasotocin
    • Fish
    • Mammals
    • Neurohypophysial hormones
    • Receptors
    • Renal function
    • Teleost


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