Neuropsin (Opn5): A novel opsin identified in mammalian neural tissue

Emma E. Tarttelin, James Bellingham, Mark W. Hankins, Russell G. Foster, Robert J. Lucas

    Research output: Contribution to journalArticlepeer-review


    We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. © 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)410-416
    Number of pages6
    JournalFEBS Letters
    Issue number3
    Publication statusPublished - 20 Nov 2003


    • Neural expression
    • Opsin
    • Photoisomerase
    • Photopigment


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