Neuropsin (Opn5): A novel opsin identified in mammalian neural tissue

Emma E. Tarttelin; James Bellingham; Mark W. Hankins; Russell G. Foster; Robert J. Lucas

doi:10.1016/S0014-5793(03)01212-2

Neuropsin (Opn5): A novel opsin identified in mammalian neural tissue

Emma E. Tarttelin, James Bellingham, Mark W. Hankins, Russell G. Foster, Robert J. Lucas

Research output: Contribution to journal › Article › peer-review

Abstract

We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. © 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	410-416
Number of pages	6
Journal	FEBS Letters
Volume	554
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(03)01212-2
Publication status	Published - 20 Nov 2003

Keywords

Neural expression
Opsin
Photoisomerase
Photopigment

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10.1016/S0014-5793(03)01212-2

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title = "Neuropsin (Opn5): A novel opsin identified in mammalian neural tissue",

abstract = "We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. {\textcopyright} 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

keywords = "Neural expression, Opsin, Photoisomerase, Photopigment",

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AU - Tarttelin, Emma E.

AU - Bellingham, James

AU - Hankins, Mark W.

AU - Foster, Russell G.

AU - Lucas, Robert J.

PY - 2003/11/20

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N2 - We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. © 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. © 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - Neural expression

KW - Opsin

KW - Photoisomerase

KW - Photopigment

U2 - 10.1016/S0014-5793(03)01212-2

DO - 10.1016/S0014-5793(03)01212-2

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VL - 554

SP - 410

EP - 416

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 3

ER -

Neuropsin (Opn5): A novel opsin identified in mammalian neural tissue

Abstract

Keywords

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