Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer

Mairead Mcnamara, AJ Templeton, M Maganti, T Walter, AM Horgan, E McKeever, T Min, E Amir, JJ Knox

    Research output: Contribution to journalArticlepeer-review


    Abstract BACKGROUND: Biliary tract cancers (BTCs) include intrahepatic (IHC), hilar, distal bile duct (DBD) and gallbladder carcinoma (GBC). Neutrophil/lymphocyte ratio (NLR), a marker of host inflammation, is prognostic in several cancers but has not been reviewed in large BTC series, or advanced BTC (ABTC) at diagnosis. PATIENTS AND METHODS: Baseline demographics and NLR at diagnosis were retrospectively evaluated in 864 consecutive patients with BTC treated from January 1987 to December 2012. The association between NLR and overall survival (OS) was determined using a multivariable Cox proportional hazards model. RESULTS: Eight hundred and sixty-four patients were included in the analysis, of which 62% had ABTC and 38% had surgery with curative intent. Median age was 65 years, 444 (51%) were male and 727 (84%) had performance status (PS) ⩽ 2. A NLR ⩾ 3.0, PS >2, IHC primary, stage, lack of surgery, haemoglobin
    Original languageEnglish
    Pages (from-to)1581-1589
    Number of pages8
    JournalEuropean Journal of Cancer
    Publication statusPublished - 2014


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