Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer

Mairead Mcnamara; AJ Templeton; M Maganti; T Walter; AM Horgan; E McKeever; T Min; E Amir; JJ Knox

doi:10.1016/j.ejca.2014.02.015

Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer

Mairead Mcnamara, AJ Templeton, M Maganti, T Walter, AM Horgan, E McKeever, T Min, E Amir, JJ Knox

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract BACKGROUND: Biliary tract cancers (BTCs) include intrahepatic (IHC), hilar, distal bile duct (DBD) and gallbladder carcinoma (GBC). Neutrophil/lymphocyte ratio (NLR), a marker of host inflammation, is prognostic in several cancers but has not been reviewed in large BTC series, or advanced BTC (ABTC) at diagnosis. PATIENTS AND METHODS: Baseline demographics and NLR at diagnosis were retrospectively evaluated in 864 consecutive patients with BTC treated from January 1987 to December 2012. The association between NLR and overall survival (OS) was determined using a multivariable Cox proportional hazards model. RESULTS: Eight hundred and sixty-four patients were included in the analysis, of which 62% had ABTC and 38% had surgery with curative intent. Median age was 65 years, 444 (51%) were male and 727 (84%) had performance status (PS) ⩽ 2. A NLR ⩾ 3.0, PS >2, IHC primary, stage, lack of surgery, haemoglobin

Original language	English
Pages (from-to)	1581-1589
Number of pages	8
Journal	European Journal of Cancer
Volume	50
DOIs	https://doi.org/10.1016/j.ejca.2014.02.015
Publication status	Published - 2014

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@article{a1910422670e4e4092d9caa386e208dd,

title = "Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer",

abstract = "Abstract BACKGROUND: Biliary tract cancers (BTCs) include intrahepatic (IHC), hilar, distal bile duct (DBD) and gallbladder carcinoma (GBC). Neutrophil/lymphocyte ratio (NLR), a marker of host inflammation, is prognostic in several cancers but has not been reviewed in large BTC series, or advanced BTC (ABTC) at diagnosis. PATIENTS AND METHODS: Baseline demographics and NLR at diagnosis were retrospectively evaluated in 864 consecutive patients with BTC treated from January 1987 to December 2012. The association between NLR and overall survival (OS) was determined using a multivariable Cox proportional hazards model. RESULTS: Eight hundred and sixty-four patients were included in the analysis, of which 62% had ABTC and 38% had surgery with curative intent. Median age was 65 years, 444 (51%) were male and 727 (84%) had performance status (PS) ⩽ 2. A NLR ⩾ 3.0, PS >2, IHC primary, stage, lack of surgery, haemoglobin",

author = "Mairead Mcnamara and AJ Templeton and M Maganti and T Walter and AM Horgan and E McKeever and T Min and E Amir and JJ Knox",

year = "2014",

doi = "10.1016/j.ejca.2014.02.015",

language = "English",

volume = "50",

pages = "1581--1589",

journal = "European Journal of Cancer",

issn = "1879-0852",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer

AU - Mcnamara, Mairead

AU - Templeton, AJ

AU - Maganti, M

AU - Walter, T

AU - Horgan, AM

AU - McKeever, E

AU - Min, T

AU - Amir, E

AU - Knox, JJ

PY - 2014

Y1 - 2014

N2 - Abstract BACKGROUND: Biliary tract cancers (BTCs) include intrahepatic (IHC), hilar, distal bile duct (DBD) and gallbladder carcinoma (GBC). Neutrophil/lymphocyte ratio (NLR), a marker of host inflammation, is prognostic in several cancers but has not been reviewed in large BTC series, or advanced BTC (ABTC) at diagnosis. PATIENTS AND METHODS: Baseline demographics and NLR at diagnosis were retrospectively evaluated in 864 consecutive patients with BTC treated from January 1987 to December 2012. The association between NLR and overall survival (OS) was determined using a multivariable Cox proportional hazards model. RESULTS: Eight hundred and sixty-four patients were included in the analysis, of which 62% had ABTC and 38% had surgery with curative intent. Median age was 65 years, 444 (51%) were male and 727 (84%) had performance status (PS) ⩽ 2. A NLR ⩾ 3.0, PS >2, IHC primary, stage, lack of surgery, haemoglobin

AB - Abstract BACKGROUND: Biliary tract cancers (BTCs) include intrahepatic (IHC), hilar, distal bile duct (DBD) and gallbladder carcinoma (GBC). Neutrophil/lymphocyte ratio (NLR), a marker of host inflammation, is prognostic in several cancers but has not been reviewed in large BTC series, or advanced BTC (ABTC) at diagnosis. PATIENTS AND METHODS: Baseline demographics and NLR at diagnosis were retrospectively evaluated in 864 consecutive patients with BTC treated from January 1987 to December 2012. The association between NLR and overall survival (OS) was determined using a multivariable Cox proportional hazards model. RESULTS: Eight hundred and sixty-four patients were included in the analysis, of which 62% had ABTC and 38% had surgery with curative intent. Median age was 65 years, 444 (51%) were male and 727 (84%) had performance status (PS) ⩽ 2. A NLR ⩾ 3.0, PS >2, IHC primary, stage, lack of surgery, haemoglobin

U2 - 10.1016/j.ejca.2014.02.015

DO - 10.1016/j.ejca.2014.02.015

M3 - Article

SN - 1879-0852

VL - 50

SP - 1581

EP - 1589

JO - European Journal of Cancer

JF - European Journal of Cancer

ER -

Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer

Abstract

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