New and emerging technologies for genetic toxicity testing

Anthony M. Lynch, Jennifer C. Sasaki, Rosalie Elespuru, David Jacobson-Kram, Véronique Thybaud, Marlies De Boeck, Marilyn J. Aardema, Jiri Aubrecht, R. Daniel Benz, Stephen D. Dertinger, George R. Douglas, Paul A. White, Patricia A. Escobar, Albert Fornace, Masamitsu Honma, Russell T. Naven, James F. Rusling, Robert H. Schiestl, Richard M. Walmsley, Eiji YamamuraJan Van Benthem, James H. Kim

    Research output: Contribution to journalArticlepeer-review


    The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. © 2010 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)205-223
    Number of pages18
    JournalEnvironmental and Molecular Mutagenesis
    Issue number3
    Publication statusPublished - Apr 2011


    • Alternatives
    • Genetic toxicity
    • New technologies
    • Testing


    Dive into the research topics of 'New and emerging technologies for genetic toxicity testing'. Together they form a unique fingerprint.

    Cite this