New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes

Neil Dixon; Tibor Pali; Stephen Ball; Michael A Harrison; Derek Marsh; John B C Findlay; Terence P Kee

doi:10.1039/b311401e

New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes

Neil Dixon, Tibor Pali, Stephen Ball, Michael A Harrison, Derek Marsh, John B C Findlay, Terence P Kee

Division of Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

New EPR spin labelled and photoactivatable molecules have been designed to probe specifically the vacuolar-H(+)-ATPase.

Original language	English
Pages (from-to)	4361-4363
Number of pages	3
Journal	Organic & biomolecular chemistry
Volume	1
Issue number	24
DOIs	https://doi.org/10.1039/b311401e
Publication status	Published - 21 Dec 2003

Keywords

Alkenes/chemical synthesis
Amides/chemical synthesis
Electron Spin Resonance Spectroscopy
Enzyme Inhibitors/chemical synthesis
Indoles/chemical synthesis
Isomerism
Models, Biological
Models, Chemical
Molecular Structure
Piperidines/chemical synthesis
Spin Labels
Structure-Activity Relationship
Temperature
Vacuolar Proton-Translocating ATPases/antagonists & inhibitors
Yeasts/drug effects

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

Access to Document

10.1039/b311401e

Cite this

@article{bb1780c483c04304a68bc38b1f732e5d,

title = "New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes",

abstract = "New EPR spin labelled and photoactivatable molecules have been designed to probe specifically the vacuolar-H(+)-ATPase.",

keywords = "Alkenes/chemical synthesis, Amides/chemical synthesis, Electron Spin Resonance Spectroscopy, Enzyme Inhibitors/chemical synthesis, Indoles/chemical synthesis, Isomerism, Models, Biological, Models, Chemical, Molecular Structure, Piperidines/chemical synthesis, Spin Labels, Structure-Activity Relationship, Temperature, Vacuolar Proton-Translocating ATPases/antagonists & inhibitors, Yeasts/drug effects",

author = "Neil Dixon and Tibor Pali and Stephen Ball and Harrison, {Michael A} and Derek Marsh and Findlay, {John B C} and Kee, {Terence P}",

year = "2003",

month = dec,

day = "21",

doi = "10.1039/b311401e",

language = "English",

volume = "1",

pages = "4361--4363",

journal = "Organic & biomolecular chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "24",

}

TY - JOUR

T1 - New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes

AU - Dixon, Neil

AU - Pali, Tibor

AU - Ball, Stephen

AU - Harrison, Michael A

AU - Marsh, Derek

AU - Findlay, John B C

AU - Kee, Terence P

PY - 2003/12/21

Y1 - 2003/12/21

N2 - New EPR spin labelled and photoactivatable molecules have been designed to probe specifically the vacuolar-H(+)-ATPase.

AB - New EPR spin labelled and photoactivatable molecules have been designed to probe specifically the vacuolar-H(+)-ATPase.

KW - Alkenes/chemical synthesis

KW - Amides/chemical synthesis

KW - Electron Spin Resonance Spectroscopy

KW - Enzyme Inhibitors/chemical synthesis

KW - Indoles/chemical synthesis

KW - Isomerism

KW - Models, Biological

KW - Models, Chemical

KW - Molecular Structure

KW - Piperidines/chemical synthesis

KW - Spin Labels

KW - Structure-Activity Relationship

KW - Temperature

KW - Vacuolar Proton-Translocating ATPases/antagonists & inhibitors

KW - Yeasts/drug effects

U2 - 10.1039/b311401e

DO - 10.1039/b311401e

M3 - Article

C2 - 14685305

SN - 1477-0520

VL - 1

SP - 4361

EP - 4363

JO - Organic & biomolecular chemistry

JF - Organic & biomolecular chemistry

IS - 24

ER -

New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes

Abstract

Keywords

Research Beacons, Institutes and Platforms

Access to Document

Fingerprint

Cite this