@article{e762894110e14472b35d4bd76043c05e,
title = "New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries",
abstract = "Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.",
keywords = "Aged, Aged, 80 and over, Case-Control Studies, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study/methods, Humans, Lung/physiopathology, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, Pulmonary Disease, Chronic Obstructive/genetics, Risk Factors, Smoking/genetics",
author = "{Understanding Society Scientific Group} and Nick Shrine and Guyatt, {Anna L} and Erzurumluoglu, {A Mesut} and Jackson, {Victoria E} and Hobbs, {Brian D} and Melbourne, {Carl A} and Chiara Batini and Fawcett, {Katherine A} and Kijoung Song and Phuwanat Sakornsakolpat and Xingnan Li and Ruth Boxall and Reeve, {Nicola F} and Ma'en Obeidat and Zhao, {Jing Hua} and Matthias Wielscher and Stefan Weiss and Kentistou, {Katherine A} and Cook, {James P} and Sun, {Benjamin B} and Jian Zhou and Jennie Hui and Stefan Karrasch and Medea Imboden and Harris, {Sarah E} and Jonathan Marten and Stefan Enroth and Kerr, {Shona M} and Ida Surakka and Veronique Vitart and Terho Lehtim{\"a}ki and Allen, {Richard J} and Bakke, {Per S} and Beaty, {Terri H} and Bleecker, {Eugene R} and Yohan Boss{\'e} and Corry-Anke Brandsma and Zhengming Chen and Crapo, {James D} and John Danesh and DeMeo, {Dawn L} and Frank Dudbridge and Ralf Ewert and Christian Gieger and Amund Gulsvik and Hansell, {Anna L} and Ke Hao and Hoffman, {Joshua D} and Hokanson, {John E} and Morris, {Andrew P}",
year = "2019",
month = mar,
day = "1",
doi = "10.1038/s41588-018-0321-7",
language = "English",
volume = "51",
pages = "481--493",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "3",
}