New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis

E. P. Das-Gupta; T. J. Lyons; J. A. Hoyland; D. M. Lawton; A. J. Freemont

New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis

E. P. Das-Gupta, T. J. Lyons, J. A. Hoyland, D. M. Lawton, A. J. Freemont

Research output: Contribution to journal › Article › peer-review

Abstract

Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.

Original language	English
Pages (from-to)	627-634
Number of pages	7
Journal	International Journal of Experimental Pathology
Volume	74
Issue number	6
Publication status	Published - 1993

Keywords

acute inflammation
knee joint
osteoarthritis model
spontaneous osteoarthritis
STR/ORT mouse
synovium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis",

abstract = "Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.",

keywords = "acute inflammation, knee joint, osteoarthritis model, spontaneous osteoarthritis, STR/ORT mouse, synovium",

author = "Das-Gupta, {E. P.} and Lyons, {T. J.} and Hoyland, {J. A.} and Lawton, {D. M.} and Freemont, {A. J.}",

year = "1993",

language = "English",

volume = "74",

pages = "627--634",

journal = "International Journal of Experimental Pathology",

issn = "0959-9673",

publisher = "John Wiley & Sons Ltd",

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New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis. / Das-Gupta, E. P.; Lyons, T. J.; Hoyland, J. A. et al.
In: International Journal of Experimental Pathology, Vol. 74, No. 6, 1993, p. 627-634.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis

AU - Das-Gupta, E. P.

AU - Lyons, T. J.

AU - Hoyland, J. A.

AU - Lawton, D. M.

AU - Freemont, A. J.

PY - 1993

Y1 - 1993

N2 - Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.

AB - Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.

KW - acute inflammation

KW - knee joint

KW - osteoarthritis model

KW - spontaneous osteoarthritis

KW - STR/ORT mouse

KW - synovium

M3 - Article

C2 - 8292560

SN - 0959-9673

VL - 74

SP - 627

EP - 634

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

IS - 6

ER -

New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis

Abstract

Keywords

UN SDGs

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