New insights into the mechanisms of action of radioimmunotherapy in lymphoma

Andrei Ivanov, Ruth Swann, Tim Illidge

    Research output: Contribution to journalArticlepeer-review


    The exquisite sensitivity of haematological malignancies to targeted radiation alongside the impressive results achieved by the pioneers in this field suggests that radioimmunotherapy is likely to be a productive area for future clinical research. Recent experimental work has demonstrated that the combination of targeted radiation and antibody effector mechanisms are critical to long-term clearance of tumour. This review provides the background of clinical and biological insights into the mechanisms of action of radioimmunotherapy. © 2008 The Authors.
    Original languageEnglish
    Pages (from-to)987-998
    Number of pages11
    JournalJournal of Pharmacy and Pharmacology
    Issue number8
    Publication statusPublished - Aug 2008


    • Algorithms
    • Animals
    • therapeutic use: Antibodies, Monoclonal
    • Decision Trees
    • Dose-Response Relationship, Drug
    • Humans
    • immunology: Lymphoma
    • methods: Radioimmunotherapy
    • therapeutic use: Radiopharmaceuticals
    • Radiotherapy Dosage
    • Treatment Outcome


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