New onset depression following myocardial infarction predicts cardiac mortality

Linda Mcgowan, Chris Dickens, Linda McGowan, Carol Percival, Barbara Tomenson, Lawrence Cotter, Anthony Heagerty, Francis Creed

    Research output: Contribution to journalArticlepeer-review


    Objective: Studies investigating the effects of depression on mortality following myocardial infarction (MI) have produced heterogeneous findings. We report on a study investigating whether the timing of the onset of depression, with regard to the MI, affected its impact on subsequent cardiac mortality. Methods: Five hundred and eighty-eight subjects admitted following MI underwent assessments of cardiac status, cardiac risk factors, and noncardiac illness. We identified separately subjects who were depressed before their MI (pre-MI depression) and those who developed depression in the 12 months after MI (new-onset depression), using a standardized questionnaire and a research interview. Patients dying of cardiac cause were identified during 8-year follow-up using information from death certificates. Results: Multivariate predictors of cardiac death during follow-up included: greater age (hazards ratio (HR) = 1.06, p =.007), previous angina (HR = 4.15, p
    Original languageEnglish
    Pages (from-to)450-455
    Number of pages5
    JournalPsychosomatic Medicine
    Issue number4
    Publication statusPublished - May 2008


    • Depression
    • Mortality
    • Myocardial infarction
    • Prognosis


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