New Reaction Pathways by Integrating Chemo- and Biocatalysis

Luis Bering, Joseph Thompson, Jason Micklefield

Research output: Contribution to journalArticlepeer-review


The combination of chemo- and biocatalysis in one-pot (integrated catalysis) is a powerful approach to develop new routes towards important products under mild and environmentally benign reaction conditions. Integrated catalysis can improve overall synthetic efficiency and, due to the complementary nature of chemo- and biocatalysts, transformations can be performed, which would be otherwise challenging using a single catalyst. In this review, we highlight recent trends for the combination of enzymes with chemocatalysts. Transition-metal catalysis, organocatalysis, and photoredox catalysis have been combined with different biocatalysts and discussed accordingly. We highlight further how integrated catalysis does not only deliver benign substitutes for known transformations but moreover enables transformations which would be otherwise impossible.
Original languageEnglish
JournalTrends in Chemistry
Publication statusAccepted/In press - 22 Feb 2022


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