New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines

Aaron Trowbridge, Scarlett M. Walton, Matthew J. Gaunt

Research output: Contribution to journalArticlepeer-review


Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from simple, readily available feedstocks have become a cornerstone of modern synthetic organic chemistry. In light of the ever-increasing importance of aliphatic amines across the range of chemical sciences, this review aims to provide a concise overview of modern transition-metal catalyzed approaches to alkylamine synthesis and their functionalization. Selected examples of amine bond forming reactions include: (a) hydroamination and hydroaminoalkylation, (b) transition-metal catalyzed C(sp3)-H functionalization, and (c) transition-metal catalyzed visible-light-mediated light photoredox catalysis.
Original languageEnglish
Pages (from-to)2613–2692
Number of pages80
JournalChemical Reviews
Issue number5
Publication statusPublished - 11 Mar 2020


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