New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

L. Ballell; R.A. Field; G.A.C. Chung; R.J. Young

doi:10.1016/j.bmcl.2006.12.066

New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

L. Ballell
, R.A. Field
, G.A.C. Chung
, R.J. Young

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

The multiple parallel synthesis of a series of N,S-bis-alkylated thiopyrazolo[3,4-d]pyrimidines, based on sequential S- then N-alkylation, is reported. These compounds showed significant anti-mycobacterial activity (MICs down to ⩽2 μg/ml) and their potential as significant drug-like leads is substantiated through cytotoxicity evaluation and in silico profiling.

Original language	Undefined
Pages (from-to)	1736-1740
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.066
Publication status	Published - 15 Mar 2007

Keywords

Anti-mycobacterial
Anti-tubercular
Thiopyrazolopyrimidines
SAR

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmcl.2006.12.066

Cite this

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abstract = "The multiple parallel synthesis of a series of N,S-bis-alkylated thiopyrazolo[3,4-d]pyrimidines, based on sequential S- then N-alkylation, is reported. These compounds showed significant anti-mycobacterial activity (MICs down to ⩽2 μg/ml) and their potential as significant drug-like leads is substantiated through cytotoxicity evaluation and in silico profiling.",

keywords = "Anti-mycobacterial, Anti-tubercular, Thiopyrazolopyrimidines, SAR",

author = "L. Ballell and R.A. Field and G.A.C. Chung and R.J. Young",

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doi = "10.1016/j.bmcl.2006.12.066",

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TY - JOUR

T1 - New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

AU - Ballell, L.

AU - Field, R.A.

AU - Chung, G.A.C.

AU - Young, R.J.

PY - 2007/3/15

Y1 - 2007/3/15

N2 - The multiple parallel synthesis of a series of N,S-bis-alkylated thiopyrazolo[3,4-d]pyrimidines, based on sequential S- then N-alkylation, is reported. These compounds showed significant anti-mycobacterial activity (MICs down to ⩽2 μg/ml) and their potential as significant drug-like leads is substantiated through cytotoxicity evaluation and in silico profiling.

AB - The multiple parallel synthesis of a series of N,S-bis-alkylated thiopyrazolo[3,4-d]pyrimidines, based on sequential S- then N-alkylation, is reported. These compounds showed significant anti-mycobacterial activity (MICs down to ⩽2 μg/ml) and their potential as significant drug-like leads is substantiated through cytotoxicity evaluation and in silico profiling.

KW - Anti-mycobacterial

KW - Anti-tubercular

KW - Thiopyrazolopyrimidines

KW - SAR

UR - https://www.scopus.com/pages/publications/33847055385

U2 - 10.1016/j.bmcl.2006.12.066

DO - 10.1016/j.bmcl.2006.12.066

M3 - Article

SN - 0960-894X

VL - 17

SP - 1736

EP - 1740

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

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