NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles:: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging

Ning-Ning Dong; Marco Pedroni; Fabio Piccinelli; Giamaica Conti; Andrea Sbarbati; Juan Enrique Ramirez-Hernandez; Laura Martinez Maestro; Maria Carmen Iglesias-de la Cruz; Francisco Sanz-Rodriguez; Angeles Juarranz; Feng Chen; Fiorenzo Vetrone; John A. Capobianco; Jose Garcia Sole; Marco Bettinelli; Daniel Jaque; Adolfo Speghini

doi:10.1021/nn202490m

NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging

Ning-Ning Dong, Marco Pedroni, Fabio Piccinelli, Giamaica Conti, Andrea Sbarbati, Juan Enrique Ramirez-Hernandez, Laura Martinez Maestro, Maria Carmen Iglesias-de la Cruz, Francisco Sanz-Rodriguez, Angeles Juarranz, Feng Chen, Fiorenzo Vetrone, John A. Capobianco, Jose Garcia Sole, Marco Bettinelli, Daniel Jaque, Adolfo Speghini

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.

Original language	English
Pages (from-to)	8665-8671
Journal	ACS Nano
Volume	5
Issue number	11
DOIs	https://doi.org/10.1021/nn202490m
Publication status	Published - Nov 2011

Keywords

multifunctional nanoprobes
fluorescence bio-imaging
nanothermometers
near-infrared upconversion
calcium fluoride

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10.1021/nn202490m

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Dong, N.-N., Pedroni, M., Piccinelli, F., Conti, G., Sbarbati, A., Enrique Ramirez-Hernandez, J., Martinez Maestro, L., Carmen Iglesias-de la Cruz, M., Sanz-Rodriguez, F., Juarranz, A., Chen, F., Vetrone, F., Capobianco, J. A., Garcia Sole, J., Bettinelli, M., Jaque, D., & Speghini, A. (2011). NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging. ACS Nano, 5(11), 8665-8671. https://doi.org/10.1021/nn202490m

@article{37014752b2264c1a84fdac17fbaa5ef8,

title = "NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles:: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging",

abstract = "In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.",

keywords = "multifunctional nanoprobes, fluorescence bio-imaging, nanothermometers, near-infrared upconversion, calcium fluoride",

author = "Ning-Ning Dong and Marco Pedroni and Fabio Piccinelli and Giamaica Conti and Andrea Sbarbati and {Enrique Ramirez-Hernandez}, Juan and {Martinez Maestro}, Laura and {Carmen Iglesias-de la Cruz}, Maria and Francisco Sanz-Rodriguez and Angeles Juarranz and Feng Chen and Fiorenzo Vetrone and Capobianco, {John A.} and {Garcia Sole}, Jose and Marco Bettinelli and Daniel Jaque and Adolfo Speghini",

year = "2011",

month = nov,

doi = "10.1021/nn202490m",

language = "English",

volume = "5",

pages = "8665--8671",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "11",

}

Dong, N-N, Pedroni, M, Piccinelli, F, Conti, G, Sbarbati, A, Enrique Ramirez-Hernandez, J, Martinez Maestro, L, Carmen Iglesias-de la Cruz, M, Sanz-Rodriguez, F, Juarranz, A, Chen, F, Vetrone, F, Capobianco, JA, Garcia Sole, J, Bettinelli, M, Jaque, D & Speghini, A 2011, 'NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging', ACS Nano, vol. 5, no. 11, pp. 8665-8671. https://doi.org/10.1021/nn202490m

TY - JOUR

T1 - NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles:

T2 - Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging

AU - Dong, Ning-Ning

AU - Pedroni, Marco

AU - Piccinelli, Fabio

AU - Conti, Giamaica

AU - Sbarbati, Andrea

AU - Enrique Ramirez-Hernandez, Juan

AU - Martinez Maestro, Laura

AU - Carmen Iglesias-de la Cruz, Maria

AU - Sanz-Rodriguez, Francisco

AU - Juarranz, Angeles

AU - Chen, Feng

AU - Vetrone, Fiorenzo

AU - Capobianco, John A.

AU - Garcia Sole, Jose

AU - Bettinelli, Marco

AU - Jaque, Daniel

AU - Speghini, Adolfo

PY - 2011/11

Y1 - 2011/11

N2 - In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.

AB - In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.

KW - multifunctional nanoprobes

KW - fluorescence bio-imaging

KW - nanothermometers

KW - near-infrared upconversion

KW - calcium fluoride

U2 - 10.1021/nn202490m

DO - 10.1021/nn202490m

M3 - Article

SN - 1936-0851

VL - 5

SP - 8665

EP - 8671

JO - ACS Nano

JF - ACS Nano

IS - 11

ER -

NIR-to-NIR Two-Photon Excited CaF2: Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging

Abstract

Keywords

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