NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline

Graziano Di Carmine; Luke Samuel Mark Forster; Simeng Wang; Christopher Parlett; Armando Carlone; Carmine D'agostino

doi:10.1039/D1RE00471A

NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline

Graziano Di Carmine, Luke Samuel Mark Forster, Simeng Wang, Christopher Parlett, Armando Carlone, Carmine D'agostino

CE - Academic & Research

Research output: Contribution to journal › Article › peer-review

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Abstract

Immobilisation of organocatalysts onto solid supports represents a very promising solution to tackle their low productivity by enabling their reuse. Herein, the use of NMR relaxation measurements, coupled with reaction screening, was used to investigate the effect of solvent interactions with the immobilised catalyst matrix on reactivity in an asymmetric organocatalysed aldol reaction. Important insights for the further development of such complex, yet promising catalytic systems are provided.

Original language	English
Journal	Reaction Chemistry & Engineering
Early online date	6 Jan 2022
DOIs	https://doi.org/10.1039/D1RE00471A
Publication status	Published - 6 Jan 2022

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10.1039/D1RE00471A

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http://pubs.rsc.org/en/Content/ArticleLanding/2022/RE/D1RE00471A

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UoMaH: The University of Manchester at Harwell
Lawrence, J. (PI), Burnett, T. (PI), Baker, M. (Researcher), Eastwood, D. (Researcher), Hunt, S. (Researcher), Yan, K. (Researcher), Khan, A. (Researcher), Ma, L. (Researcher), Mirihanage, W. (Researcher), Parlett, C. (Researcher), Freitas, D. (Researcher), Reinhard, C. (Support team), Duggins, D. (Technical team), Lewis-Fell, J. (Technical team), Nonni, S. (Technical team), Rollings, B. (Technical team), Sinclair, L. (Technical team) & Batts, S. (Support team)
1/01/18 → …
Project: Other
In-situ NMR-based methodology for screening and optimisation of heterogenised organocatalytic systems
D'Agostino, C. (PI)
1/06/19 → 30/05/21
Project: Research

Cite this

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title = "NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline",

abstract = "Immobilisation of organocatalysts onto solid supports represents a very promising solution to tackle their low productivity by enabling their reuse. Herein, the use of NMR relaxation measurements, coupled with reaction screening, was used to investigate the effect of solvent interactions with the immobilised catalyst matrix on reactivity in an asymmetric organocatalysed aldol reaction. Important insights for the further development of such complex, yet promising catalytic systems are provided.",

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AU - Di Carmine, Graziano

AU - Forster, Luke Samuel Mark

AU - Wang, Simeng

AU - Parlett, Christopher

AU - Carlone, Armando

AU - D'agostino, Carmine

PY - 2022/1/6

Y1 - 2022/1/6

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AB - Immobilisation of organocatalysts onto solid supports represents a very promising solution to tackle their low productivity by enabling their reuse. Herein, the use of NMR relaxation measurements, coupled with reaction screening, was used to investigate the effect of solvent interactions with the immobilised catalyst matrix on reactivity in an asymmetric organocatalysed aldol reaction. Important insights for the further development of such complex, yet promising catalytic systems are provided.

U2 - 10.1039/D1RE00471A

DO - 10.1039/D1RE00471A

M3 - Article

SN - 2058-9883

JO - Reaction Chemistry & Engineering

JF - Reaction Chemistry & Engineering

ER -

NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline

Abstract

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UoMaH: The University of Manchester at Harwell

In-situ NMR-based methodology for screening and optimisation of heterogenised organocatalytic systems

Cite this