No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

Barbara I. Nicholl; Kate L. Holliday; Gary J. Macfarlane; Wendy Thomson; Kelly A. Davies; Terence W. O'Neill; Gyorgy Bartfai; Steven Boonen; Felipe Casanueva; Joseph D. Finn; Gianni Forti; Aleksander Giwercman; Ilpo T. Huhtaniemi; Krzysztof Kula; Margus Punab; Alan J. Silman; Dirk Vanderschueren; Frederick C W Wu; John McBeth; Luisa Petrone; Antonio Cilotti; Herman Borghs; Jolanta Slowikowska-Hilczer; Renata Walczak-Jedrzejowska; Philip Steer; Abdelouahid Tajar; David Lee; Stephen Pye; Marta Ocampo; Mary Lage; Imre Földesi; Imre Fejes; Paul Korrovitz; Min Jiang

doi:10.1136/ard.2009.126086

No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

Barbara I. Nicholl, Kate L. Holliday, Gary J. Macfarlane, Wendy Thomson, Kelly A. Davies, Terence W. O'Neill, Gyorgy Bartfai, Steven Boonen, Felipe Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Ilpo T. Huhtaniemi, Krzysztof Kula, Margus Punab, Alan J. Silman, Dirk Vanderschueren, Frederick C W Wu, John McBeth, Luisa PetroneAntonio Cilotti, Herman Borghs, Jolanta Slowikowska-Hilczer, Renata Walczak-Jedrzejowska, Philip Steer, Abdelouahid Tajar, David Lee, Stephen Pye, Marta Ocampo, Mary Lage, Imre Földesi, Imre Fejes, Paul Korrovitz, Min Jiang

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods: Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results: No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions: There was no evidence of association between the COMT 'pain sensitivity' haplotypes and CWP in two population-based cohorts.

Original language	English
Pages (from-to)	2009-2012
Number of pages	3
Journal	Annals of the rheumatic diseases
Volume	69
Issue number	11
DOIs	https://doi.org/10.1136/ard.2009.126086
Publication status	Published - Nov 2010

Keywords

EMAS
INCOMPLETE
ORIGINAL ARTICLES

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10.1136/ard.2009.126086

http://ard.bmj.com/content/69/11/2009.full.pdf

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Nicholl, B. I., Holliday, K. L., Macfarlane, G. J., Thomson, W., Davies, K. A., O'Neill, T. W., Bartfai, G., Boonen, S., Casanueva, F., Finn, J. D., Forti, G., Giwercman, A., Huhtaniemi, I. T., Kula, K., Punab, M., Silman, A. J., Vanderschueren, D., Wu, F. C. W., McBeth, J., ... Jiang, M. (2010). No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain. Annals of the rheumatic diseases, 69(11), 2009-2012. https://doi.org/10.1136/ard.2009.126086

@article{136d5e50007842c98f7cf96eb0e9a669,

title = "No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain",

abstract = "Objectives: The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods: Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results: No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions: There was no evidence of association between the COMT 'pain sensitivity' haplotypes and CWP in two population-based cohorts.",

keywords = "EMAS, INCOMPLETE, ORIGINAL ARTICLES",

author = "Nicholl, {Barbara I.} and Holliday, {Kate L.} and Macfarlane, {Gary J.} and Wendy Thomson and Davies, {Kelly A.} and O'Neill, {Terence W.} and Gyorgy Bartfai and Steven Boonen and Felipe Casanueva and Finn, {Joseph D.} and Gianni Forti and Aleksander Giwercman and Huhtaniemi, {Ilpo T.} and Krzysztof Kula and Margus Punab and Silman, {Alan J.} and Dirk Vanderschueren and Wu, {Frederick C W} and John McBeth and Luisa Petrone and Antonio Cilotti and Herman Borghs and Jolanta Slowikowska-Hilczer and Renata Walczak-Jedrzejowska and Philip Steer and Abdelouahid Tajar and David Lee and Stephen Pye and Marta Ocampo and Mary Lage and Imre F{\"o}ldesi and Imre Fejes and Paul Korrovitz and Min Jiang",

year = "2010",

month = nov,

doi = "10.1136/ard.2009.126086",

language = "English",

volume = "69",

pages = "2009--2012",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

number = "11",

}

Nicholl, BI, Holliday, KL, Macfarlane, GJ, Thomson, W, Davies, KA, O'Neill, TW, Bartfai, G, Boonen, S, Casanueva, F, Finn, JD, Forti, G, Giwercman, A, Huhtaniemi, IT, Kula, K, Punab, M, Silman, AJ, Vanderschueren, D, Wu, FCW , McBeth, J, Petrone, L, Cilotti, A, Borghs, H, Slowikowska-Hilczer, J, Walczak-Jedrzejowska, R, Steer, P, Tajar, A, Lee, D, Pye, S, Ocampo, M, Lage, M, Földesi, I, Fejes, I, Korrovitz, P & Jiang, M 2010, 'No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain', Annals of the rheumatic diseases, vol. 69, no. 11, pp. 2009-2012. https://doi.org/10.1136/ard.2009.126086

TY - JOUR

T1 - No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

AU - Nicholl, Barbara I.

AU - Holliday, Kate L.

AU - Macfarlane, Gary J.

AU - Thomson, Wendy

AU - Davies, Kelly A.

AU - O'Neill, Terence W.

AU - Bartfai, Gyorgy

AU - Boonen, Steven

AU - Casanueva, Felipe

AU - Finn, Joseph D.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

AU - Punab, Margus

AU - Silman, Alan J.

AU - Vanderschueren, Dirk

AU - Wu, Frederick C W

AU - McBeth, John

AU - Petrone, Luisa

AU - Cilotti, Antonio

AU - Borghs, Herman

AU - Slowikowska-Hilczer, Jolanta

AU - Walczak-Jedrzejowska, Renata

AU - Steer, Philip

AU - Tajar, Abdelouahid

AU - Lee, David

AU - Pye, Stephen

AU - Ocampo, Marta

AU - Lage, Mary

AU - Földesi, Imre

AU - Fejes, Imre

AU - Korrovitz, Paul

AU - Jiang, Min

PY - 2010/11

Y1 - 2010/11

N2 - Objectives: The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods: Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results: No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions: There was no evidence of association between the COMT 'pain sensitivity' haplotypes and CWP in two population-based cohorts.

AB - Objectives: The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods: Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results: No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions: There was no evidence of association between the COMT 'pain sensitivity' haplotypes and CWP in two population-based cohorts.

KW - EMAS

KW - INCOMPLETE

KW - ORIGINAL ARTICLES

U2 - 10.1136/ard.2009.126086

DO - 10.1136/ard.2009.126086

M3 - Article

SN - 0003-4967

VL - 69

SP - 2009

EP - 2012

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 11

ER -

No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

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