No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder

Antony Payton; Darko Turic; Kate Langley; Sophie Mills; Deborah C. Lawson; Marianne Van Den Bree; Michael J. Owen; Michael C. O'Donovan; William Ollier; Jane Worthington; Anita Thapar

doi:10.1097/00041444-200309000-00009

No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder

Antony Payton, Darko Turic, Kate Langley, Sophie Mills, Deborah C. Lawson, Marianne Van Den Bree, Michael J. Owen, Michael C. O'Donovan, William Ollier, Jane Worthington, Anita Thapar

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. Methods: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. Results: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. Conclusion: There was no evidence of association of HLA-DRB1 and ADHD. © 2003 Lippincott Williams & Wilkins.

Original language	English
Pages (from-to)	183-185
Number of pages	2
Journal	Psychiatric Genetics
Volume	13
Issue number	3
DOIs	https://doi.org/10.1097/00041444-200309000-00009
Publication status	Published - Sept 2003

Keywords

Association study
Attention deficit hyperactivity disorder
Human leukocyte antigen
Molecular genetics
Transmission Disequilibrium Test

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10.1097/00041444-200309000-00009

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title = "No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder",

abstract = "Objectives: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. Methods: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. Results: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. Conclusion: There was no evidence of association of HLA-DRB1 and ADHD. {\textcopyright} 2003 Lippincott Williams & Wilkins.",

keywords = "Association study, Attention deficit hyperactivity disorder, Human leukocyte antigen, Molecular genetics, Transmission Disequilibrium Test",

author = "Antony Payton and Darko Turic and Kate Langley and Sophie Mills and Lawson, {Deborah C.} and {Van Den Bree}, Marianne and Owen, {Michael J.} and O'Donovan, {Michael C.} and William Ollier and Jane Worthington and Anita Thapar",

year = "2003",

month = sep,

doi = "10.1097/00041444-200309000-00009",

language = "English",

volume = "13",

pages = "183--185",

journal = "Psychiatric Genetics",

issn = "1473-5873",

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number = "3",

}

TY - JOUR

T1 - No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder

AU - Payton, Antony

AU - Turic, Darko

AU - Langley, Kate

AU - Mills, Sophie

AU - Lawson, Deborah C.

AU - Van Den Bree, Marianne

AU - Owen, Michael J.

AU - O'Donovan, Michael C.

AU - Ollier, William

AU - Worthington, Jane

AU - Thapar, Anita

PY - 2003/9

Y1 - 2003/9

N2 - Objectives: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. Methods: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. Results: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. Conclusion: There was no evidence of association of HLA-DRB1 and ADHD. © 2003 Lippincott Williams & Wilkins.

AB - Objectives: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. Methods: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. Results: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. Conclusion: There was no evidence of association of HLA-DRB1 and ADHD. © 2003 Lippincott Williams & Wilkins.

KW - Association study

KW - Attention deficit hyperactivity disorder

KW - Human leukocyte antigen

KW - Molecular genetics

KW - Transmission Disequilibrium Test

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DO - 10.1097/00041444-200309000-00009

M3 - Article

SN - 1473-5873

VL - 13

SP - 183

EP - 185

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 3

ER -

No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder

Abstract

Keywords

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