No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age

P. M. Mannucci, P. A. Merlini, D. Ardissino, C. Barzuini, F. Bernardi, L. Bernardinelli, C. Cavallini, P. Celli, G. Corsini, M. Ferrario, R. Fetiveau, M. Galli, A. Piazza, F. Ribichini, E. Sacchi, M. Tubaro, P. Zonzin, C. Berzuini, L. Foco, L. TagliabueM. Menegatti, F. Peyvandi, A. Repetto, U. Canosi, V. Cucci, S. Buratti, S. Fondazione, M. Ponzetta, M. Rinuncini, M. Spolverato, A. Vetrano, M. Lamponi, L. Cacciavillani, C. Castelli, A. Colizzi, N. Pagnoni, E. Colombi, D. Covini, G. Fantini, C. Dodi, P. Paoloni, I. Maoddi, G. Bardelli, M. Azzarito, M. Beciani, F. Tettamanti, M. E. Caccia, P. Massoli, R. Pozzi, F. Pecchio, P. Barberis, M. Giudice, R. Di Giovanbattista, B. Mazzocco, G. Gaeta, M. Margaglione, P. Diotallevi, A. Salvioni, S. Biancoli, A. Rosi, E. Milanesi, S. Span, A. C M Saccà, A. C. Maugeri, D. Scorzoni, M. Maffi, G. A. Dei Tos, P. P. Cannarozzo, R. Vandelli, M. Fici, A. Tempesta, G. R. Lucchi, G. Ricci, D. Baragli, D. Laiso, L. Garzaro, R. Vaninetti, G. Cattadori, A. Picozzi, R. Petacchi, C. Berardi, V. Guiducci, O. Gaddi, N. Franco, E. Buia, F. Fedeli, F. Barillà, L. Irace, S. Sarracino, N. De Giorgio, G. Scalera, M. Elia, P. Sabella, A. Previtera, G. Di Tano, B. Francaviglia, G. Contini, F. Del Nevo, P. Agricola

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background - We investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic predisposition to a prothrombotic state. Methods and Results - This nationwide case-control study involved 1210 patients who had survived a first myocardial infarction at an age of
    Original languageEnglish
    Pages (from-to)1117-1122
    Number of pages5
    JournalCirculation
    Volume107
    Issue number8
    DOIs
    Publication statusPublished - 4 Mar 2003

    Keywords

    • Coagulation
    • Fibrinolysis
    • Genes
    • Myocardial infarction
    • Platelets

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