TY - JOUR
T1 - No evidence of improvement in neuropathy after renal transplantation in patients with end stage kidney disease
AU - Ferdousi, Maryam
AU - Azmi, Shazli
AU - Kalteniece, Alise
AU - Khan, Saif Ullah
AU - Petropoulos, Ioannis N.
AU - Ponirakis, Georgios
AU - Alam, Uazman
AU - Asghar, Omar
AU - Marshall, Andrew
AU - Soran, Handrean
AU - Boulton, Andrew J.M.
AU - Augustine, Titus
AU - Malik, Rayaz A.
N1 - Funding Information:
Supported by the Manchester Biomedical Research Centre and the Greater Manchester Comprehensive Local Research Network. The authors alone are responsible for the content and writing of the article. Dr Mitra Tavakoli undertook corneal confocal microscopy and Dr Hassan Fadavi undertook clinical assessment and QST in a proportion of patients. This research was funded by an award from the National Institutes of Health (R1‐05991).
Publisher Copyright:
© 2021 Peripheral Nerve Society.
PY - 2021/6/4
Y1 - 2021/6/4
N2 - To assess the impact of renal transplantation on peripheral nerve damage in patients with chronic kidney disease (CKD). Fifteen patients with CKD (eGFR <15 mL/min/1.73 m2) underwent longitudinal assessment after renal transplantation (age: 56.88 ± 2.53 years, eGFR: 46.82 ± 4.86) and were compared with 15 age-matched controls (age: 58.25 ± 2.18 years, eGFR: 86.0 ± 2.0). The neuropathy symptom profile (NSP), neuropathy disability score (NDS), vibration perception threshold (VPT), cold and warm sensation threshold (CST and WST), cold and heat induced pain (CIP and HIP), deep breathing heart rate variability (DB-HRV), nerve conduction studies and corneal confocal microscopy (CCM) to quantify small nerve fibre pathology, were undertaken within 1-month of renal transplantation (baseline) and at 6, 12 and 24 months of follow up. There was no significant difference in NSP (P =.1), NDS (P =.3), VPT (P =.6), CST (P =.2), CIP (P =.08), HIP (P =.1), DB-HRV (P =.9) and sural (P =.4) and peroneal (P =.1) nerve amplitude between patients with CKD and controls at baseline. However, sural (P =.04), peroneal (P =.002) and tibial (P =.007) nerve conduction velocity and tibial nerve amplitude (P =.03) were significantly lower, WST (P =.02) was significantly higher and corneal nerve fibre density (P =.004) was significantly lower in patients with CKD compared with controls. There was no significant change in NSP, NDS, quantitative sensory testing, DB-HRV, nerve conduction or CCM parameters 24 months after renal transplantation. There is evidence of small and large fibre neuropathy in patients with CKD, but no change up to 24 months after successful renal transplantation.
AB - To assess the impact of renal transplantation on peripheral nerve damage in patients with chronic kidney disease (CKD). Fifteen patients with CKD (eGFR <15 mL/min/1.73 m2) underwent longitudinal assessment after renal transplantation (age: 56.88 ± 2.53 years, eGFR: 46.82 ± 4.86) and were compared with 15 age-matched controls (age: 58.25 ± 2.18 years, eGFR: 86.0 ± 2.0). The neuropathy symptom profile (NSP), neuropathy disability score (NDS), vibration perception threshold (VPT), cold and warm sensation threshold (CST and WST), cold and heat induced pain (CIP and HIP), deep breathing heart rate variability (DB-HRV), nerve conduction studies and corneal confocal microscopy (CCM) to quantify small nerve fibre pathology, were undertaken within 1-month of renal transplantation (baseline) and at 6, 12 and 24 months of follow up. There was no significant difference in NSP (P =.1), NDS (P =.3), VPT (P =.6), CST (P =.2), CIP (P =.08), HIP (P =.1), DB-HRV (P =.9) and sural (P =.4) and peroneal (P =.1) nerve amplitude between patients with CKD and controls at baseline. However, sural (P =.04), peroneal (P =.002) and tibial (P =.007) nerve conduction velocity and tibial nerve amplitude (P =.03) were significantly lower, WST (P =.02) was significantly higher and corneal nerve fibre density (P =.004) was significantly lower in patients with CKD compared with controls. There was no significant change in NSP, NDS, quantitative sensory testing, DB-HRV, nerve conduction or CCM parameters 24 months after renal transplantation. There is evidence of small and large fibre neuropathy in patients with CKD, but no change up to 24 months after successful renal transplantation.
KW - corneal confocal microscopy
KW - corneal nerve
KW - neuropathy
KW - renal failure
KW - renal transplantation
U2 - 10.1111/jns.12456
DO - 10.1111/jns.12456
M3 - Article
AN - SCOPUS:85107498420
SN - 1085-9489
JO - Journal of the Peripheral Nervous System
JF - Journal of the Peripheral Nervous System
ER -
