No role for interleukin-18 in acute murine stroke-induced brain injury

RD Wheeler, H Boutin, Omar Touzani, GN Luheshi, K. Takeda, NJ Rothwell

Research output: Contribution to journalArticlepeer-review


There is now extensive evidence to show that the cytokine interleukin-1 (IL-1) contributes directly to reversible and permanent ischemic brain damage in rodents. Because interleukin-18 (IL-18) shares many structural and functional similarities with IL-1, the authors tested the hypothesis that IL-18 contributes directly to ischemic brain damage in mice exposed to focal, reversible (15-minute or 30-minute) middle cerebral artery occlusion. IL-18 expression was not induced acutely by middle cerebral artery occlusion, and deletion of the IL-18 gene (IL-18 knockout mice) did not affect infarct volume. The present results suggest that IL-18 does not contribute to acute ischemic brain damage.
Original languageEnglish
Pages (from-to)531-535
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
Publication statusPublished - May 2003


  • Cytokines
  • Interleukin-18
  • Knockout mice
  • Stroke


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